Area of research
Molecular Biology · Immunology
Research interest
Research interests include Genomics and Chromatin Dynamics, T-cell and B-cell Immunology, Immune Cell Function and Interaction, and Epigenetics and DNA Methylation.
Binding domain mutations provide insight into CTCF’s relationship with chromatin and its contribution to gene regulation
Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening
CRISPR and biochemical screens identify MAZ as a cofactor in CTCF-mediated insulation at Hox clusters
DNA methylation disruption reshapes the hematopoietic differentiation landscape
Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation
Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency
RNA Interactions Are Essential for CTCF-Mediated Genome Organization
NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage
EpiMethylTag: simultaneous detection of ATAC-seq or ChIP-seq signals with DNA methylation
Capturing the Onset of PRC2-Mediated Repressive Domain Formation
Analysis of 3D genomic interactions identifies candidate host genes that transposable elements potentially regulate
Control of B-1a cell development by instructive BCR signaling
Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development
Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2
Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development
The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect
CRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual loci
MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis
4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments
Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions
Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation
miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation
Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination
A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination
miRNAs are critical for the regulation of RAG expression and secondary Ig rearrangement in peripheral B lymphocytes
CTCF establishes discrete functional chromatin domains at the <i>Hox</i> clusters during differentiation
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms
Long-Range Regulation of V(D)J Recombination