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James J. Harding

Florida State University · US
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Area of research
Surgery · Oncology
Research interest
Research interests include Cholangiocarcinoma and Gallbladder Cancer Studies, Hepatocellular Carcinoma Treatment and Prognosis, Cancer Genomics and Diagnostics, and Cancer Immunotherapy and Biomarkers.
h-index
54
citations
17,766
works
543
NIH funding
primary concept
Medicine
email

Recent publications

Final Results from a First-in-Human Phase I Study of the Dual Isocitrate Dehydrogenase (IDH) 1/2 Inhibitor, LY3410738, in Advanced Solid Tumors Harboring <i>IDH1</i> or <i>IDH2</i> Mutations
Clinical Cancer Research 2025cited by 5position: firstdoi
Zanidatamab in previously-treated HER2-positive (HER2+) biliary tract cancer (BTC): Overall survival (OS) and longer follow-up from the phase 2b HERIZON-BTC-01 study.
Journal of Clinical Oncology 2024cited by 19position: lastdoi
Zanidatamab for HER2-amplified, unresectable, locally advanced or metastatic biliary tract cancer (HERIZON-BTC-01): a multicentre, single-arm, phase 2b study
The Lancet Oncology 2023cited by 232position: firstdoi
Antitumour activity of neratinib in patients with HER2-mutant advanced biliary tract cancers
Nature Communications 2023cited by 81position: firstdoi
Abstract CT098: A first-in-human phase 1 study of LY3410738, a covalent inhibitor of mutant IDH, in advanced IDH-mutant cholangiocarcinoma and other solid tumors
Cancer Research 2023cited by 13position: lastdoi
SO-1 A first-in-human phase 1 study of LY3410738, a covalent inhibitor of mutant IDH1 and IDH2, as monotherapy and in combination with cisplatin and gemcitabine in advanced IDH-mutant cholangiocarcinoma
Annals of Oncology 2023cited by 9position: firstdoi
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients
Cell 2022cited by 637position: middledoi
Rational development of combination therapies for biliary tract cancers
Journal of Hepatology 2022cited by 71position: firstdoi
Tremelimumab and Durvalumab in the Treatment of Unresectable, Advanced Hepatocellular Carcinoma
Future Oncology 2022cited by 45position: middledoi
Comprehensive Molecular Characterization of Gallbladder Carcinoma and Potential Targets for Intervention
Clinical Cancer Research 2022cited by 44position: middledoi
Characterization, management, and risk factors of hyperglycemia during <scp>PI3K</scp> or <scp>AKT</scp> inhibitor treatment
Cancer Medicine 2022cited by 39position: middledoi
First-In-Human Effects of PPT1 Inhibition Using the Oral Treatment with GNS561/Ezurpimtrostat in Patients with Primary and Secondary Liver Cancers
Liver Cancer 2022cited by 30position: firstdoi
A Phase 1 Dose-Escalation Study of PF-06671008, a Bispecific T-Cell-Engaging Therapy Targeting P-Cadherin in Patients With Advanced Solid Tumors
Frontiers in Immunology 2022cited by 16position: firstdoi
Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma
Hepatology 2021cited by 160position: middledoi
Blocking TIM-3 in Treatment-refractory Advanced Solid Tumors: A Phase Ia/b Study of LY3321367 with or without an Anti-PD-L1 Antibody
Clinical Cancer Research 2021cited by 157position: firstdoi
OncoTree: A Cancer Classification System for Precision Oncology
JCO Clinical Cancer Informatics 2021cited by 145position: middledoi
CD8-targeted PET Imaging of Tumor Infiltrating T cells in Patients with Cancer: A Phase I First-in-Human Study of <sup>89</sup>Zr-Df-IAB22M2C, a Radiolabeled anti-CD8 Minibody
Journal of Nuclear Medicine 2021cited by 119position: middledoi
A Phase I Dose-Escalation and Expansion Study of Telaglenastat in Patients with Advanced or Metastatic Solid Tumors
Clinical Cancer Research 2021cited by 82position: firstdoi
Phase II Clinical Trial of Everolimus in a Pan-Cancer Cohort of Patients with mTOR Pathway Alterations
Clinical Cancer Research 2021cited by 55position: middledoi
Phase 1b study of galunisertib and ramucirumab in patients with advanced hepatocellular carcinoma
Cancer Medicine 2021cited by 45position: firstdoi
A phase I study of LY3410738, a first-in-class covalent inhibitor of mutant IDH1 in cholangiocarcinoma and other advanced solid tumors.
Journal of Clinical Oncology 2021cited by 24position: lastdoi
A phase III, double-blind, randomized study of nivolumab (NIVO) and ipilimumab (IPI), nivo monotherapy or placebo plus transarterial chemoembolization (TACE) in patients with intermediate-stage hepatocellular carcinoma (HCC).
Journal of Clinical Oncology 2021cited by 19position: middledoi
Genomic Methods Identify Homologous Recombination Deficiency in Pancreas Adenocarcinoma and Optimize Treatment Selection
Clinical Cancer Research 2020cited by 222position: middledoi
Characterization of on-target adverse events caused by TRK inhibitor therapy
Annals of Oncology 2020cited by 86position: middledoi
LBA-3 CheckMate 459: Long-term (minimum follow-up 33.6 months) survival outcomes with nivolumab versus sorafenib as first-line treatment in patients with advanced hepatocellular carcinoma
Annals of Oncology 2020cited by 58position: middledoi
Phase II Multicenter, Open-Label Study of Oral ENMD-2076 for the Treatment of Patients with Advanced Fibrolamellar Carcinoma
The Oncologist 2020cited by 44position: middledoi
CheckMate 459: A randomized, multi-center phase III study of nivolumab (NIVO) vs sorafenib (SOR) as first-line (1L) treatment in patients (pts) with advanced hepatocellular carcinoma (aHCC)
Annals of Oncology 2019cited by 646position: middledoi
TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion–Positive Intrahepatic Cholangiocarcinoma
Cancer Discovery 2019cited by 368position: middledoi
First-in-Humans Imaging with <sup>89</sup>Zr-Df-IAB22M2C Anti-CD8 Minibody in Patients with Solid Malignancies: Preliminary Pharmacokinetics, Biodistribution, and Lesion Targeting
Journal of Nuclear Medicine 2019cited by 260position: middledoi
Assessment of Treatment With Sorafenib Plus Doxorubicin vs Sorafenib Alone in Patients With Advanced Hepatocellular Carcinoma
JAMA Oncology 2019cited by 119position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Ghassan K. Abou‐Alfa · Verizon (United States)15 papers (2015–2022)Eileen M. O’Reilly · Erasmus MC Cancer Institute7 papers (2017–2022)Robin Kate Kelley · UCSF Helen Diller Family Comprehensive Cancer Center6 papers (2016–2021)Funda Meric‐Bernstam · Breast Cancer Care5 papers (2015–2021)Pamela N. Münster · UCSF Helen Diller Family Comprehensive Cancer Center5 papers (2015–2021)David B. Solit · New York Oncology Hematology5 papers (2012–2018)Melinda L. Telli · Stanford University5 papers (2015–2021)Richard D. Carvajal · Northwell Health4 papers (2015–2019)Martin H. Voss · Spanish Oncology Genitourinary Group4 papers (2016–2021)Jeffrey R. Infante · Janssen (United States)4 papers (2015–2021)Alan P. Venook · University of California, San Francisco4 papers (2016–2020)Angela DeMichele · Brigham and Women's Hospital4 papers (2015–2021)Manish R. Patel · Centers for Disease Control and Prevention4 papers (2015–2019)Michael F. Berger · Memorial Sloan Kettering Cancer Center4 papers (2014–2022)Mark K. Bennett · Dalhousie University4 papers (2015–2021)David M. Hyman · Mayo Clinic in Florida3 papers (2018–2021)Julien Edeline · University of Genoa3 papers (2019–2021)Richard S. Finn · United States Olympic & Paralympic Committee3 papers (2019–2021)Damir Begic · Bristol-Myers Squibb (United States)3 papers (2019–2021)Paul B. Chapman · Weill Cornell Medicine3 papers (2012–2015)
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