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Jeffrey M. Friedman

Howard Hughes Medical Institute · US
Area of research
Endocrine and Autonomic Systems · Physiology
Research interest
Research interests include Regulation of Appetite and Obesity, Adipose Tissue and Metabolism, Biochemical Analysis and Sensing Techniques, and Adipokines, Inflammation, and Metabolic Diseases.
h-index
100
citations
71,729
works
327
NIH funding
primary concept
email

Recent publications

Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice
Nature Communications 2026cited by 1position: middledoi
A cellular and molecular basis of leptin resistance
Cell Metabolism 2025cited by 23position: lastdoi
On the causes of obesity and its treatment: The end of the beginning
Cell Metabolism 2025cited by 21position: firstdoi
Non-invasive in vivo bidirectional magnetogenetic modulation of pain circuits
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 0position: middledoi
Identification of a Thermogenic Target in the Dorsal Raphe Nucleus for Weight Management
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 0position: middledoi
Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake
Nature 2024cited by 66position: lastdoi
Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need
Science 2024cited by 55position: middledoi
A subcortical feeding circuit linking an interoceptive node to jaw movement
Nature 2024cited by 23position: lastdoi
Bidirectional regulation of motor circuits using magnetogenetic gene therapy
Science Advances 2024cited by 15position: middledoi
Leptin signaling maintains autonomic stability during severe influenza infection in mice
Journal of Clinical Investigation 2024cited by 3position: middledoi
FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system
Cell Metabolism 2023cited by 50position: middledoi
Seeking satiety: From signals to solutions
Science Translational Medicine 2023cited by 23position: lastdoi
Drugs of abuse hijack a mesolimbic pathway that processes homeostatic need
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 8position: middledoi
Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy
bioRxiv (Cold Spring Harbor Laboratory) 2023cited by 6position: middledoi
Brainstem ADCYAP1+ neurons control multiple aspects of sickness behaviour
Nature 2022cited by 136position: lastdoi
Dynamic processing of hunger and thirst by common mesolimbic neural ensembles
Proceedings of the National Academy of Sciences 2022cited by 26position: lastdoi
Pharmacological targeting of glutamatergic neurons within the brainstem for weight reduction
Nature Metabolism 2022cited by 25position: lastdoi
Higher-Order Inputs Involved in Appetite Control
Biological Psychiatry 2021cited by 39position: middledoi
Functional analysis of distinct populations of subthalamic nucleus neurons on Parkinson’s disease and OCD-like behaviors in mice
Molecular Psychiatry 2021cited by 35position: lastdoi
How the discovery of microbial opsins led to the development of optogenetics
Cell 2021cited by 11position: firstdoi
A limbic circuit selectively links active escape to food suppression
eLife 2020cited by 94position: middledoi
Gut-to-brain signals in feeding control
American Journal of Physiology-Endocrinology and Metabolism 2020cited by 38position: middledoi
Uncovering a possible role of reactive oxygen species in magnetogenetics
Scientific Reports 2020cited by 36position: middledoi
Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo
Advanced Science 2020cited by 13position: middledoi
Limitation of adipose tissue by the number of embryonic progenitor cells
eLife 2020cited by 12position: lastdoi
Leptin and the endocrine control of energy balance
Nature Metabolism 2019cited by 623position: firstdoi
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity
Nature Medicine 2019cited by 107position: lastdoi
Regulation of Energy Expenditure by Brainstem GABA Neurons
Cell 2019cited by 105position: middledoi
α1- and β3-Adrenergic Receptor–Mediated Mesolimbic Homeostatic Plasticity Confers Resilience to Social Stress in Susceptible Mice
Biological Psychiatry 2018cited by 87position: middledoi
Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons
Molecular Metabolism 2018cited by 46position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

Alexander R. Nectow · Columbia University Irving Medical Center10 papers (2012–2022)Lisa E. Pomeranz · Rockefeller University9 papers (2012–2025)Sarah A. Stanley · Icahn School of Medicine at Mount Sinai8 papers (2012–2025)Mats I. Ekstrand · Rockefeller University8 papers (2012–2017)Marc Schneeberger · Yale University8 papers (2017–2025)Ana I. Domingos · University of Oxford6 papers (2012–2018)Leah Kelly · Howard Hughes Medical Institute6 papers (2013–2025)Yi-Hsueh Lu · Rockefeller University6 papers (2015–2020)Eric J. Nestler · Allen Institute for Brain Science6 papers (2012–2024)Xiaofei Yu · Weifang People's Hospital6 papers (2016–2024)Bowen Tan · Jilin University5 papers (2020–2025)Luca Parolari · Rockefeller University5 papers (2018–2025)Kıvanç Birsoy · Rockefeller University5 papers (2012–2020)Zachary A. Knight · Howard Hughes Medical Institute5 papers (2012–2024)Kyle Pellegrino · University of North Carolina at Chapel Hill4 papers (2019–2025)Estefania P. Azevedo · Medical University of South Carolina4 papers (2017–2021)Keith Tan · Rockefeller University4 papers (2012–2018)Putianqi Wang · Howard Hughes Medical Institute4 papers (2019–2024)Nathaniel Heintz · Rockefeller University4 papers (2017–2025)Nicolas Renier · Institut de Myologie4 papers (2017–2025)