Area of research
Molecular Biology · Pharmacology
Research interest
Research interests include Microbial Natural Products and Biosynthesis, RNA and protein synthesis mechanisms, Biochemical and Molecular Research, and Enzyme Structure and Function.
Discovery of the Phosphonate Flavophos Produced by <i>Burkholderia</i>
Genetic and biochemical characterization of a radical SAM enzyme required for post-translational glutamine methylation of methyl-coenzyme M reductase
Combatting virulent gut bacteria by inhibiting the biosynthesis of a two-component lanthipeptide toxin
Catalysts for the Enzymatic Lipidation of Peptides
Class V Lanthipeptide Cyclase Directs the Biosynthesis of a Stapled Peptide Natural Product
Tail-Tape-Fused Virion and Non-Virion RNA Polymerases of a Thermophilic Virus
LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome
Structural and mechanistic investigations of protein S-glycosyltransferases
New developments in RiPP discovery, enzymology and engineering
Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease
Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics
Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post‐translationally Modified Peptides in <i>Lachnospiraceae</i>
The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis
Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis
A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases
Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes
Structural insights into enzymatic [4+2] <i>aza</i> -cycloaddition in thiopeptide antibiotic biosynthesis
Enzymatic N- and C-Protection in Cyanobactin RiPP Natural Products
Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis
Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis
Molecular basis for the broad substrate selectivity of a peptide prenyltransferase
Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads
The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold
Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage
A Common Late-Stage Intermediate in Catalysis by 2-Hydroxyethyl-phosphonate Dioxygenase and Methylphosphonate Synthase
Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB
Structure and mechanism of lanthipeptide biosynthetic enzymes
Substrate Specificity of the Lanthipeptide Peptidase ElxP and the Oxidoreductase ElxO
Chemical Rescue and Inhibition Studies to Determine the Role of Arg301 in Phosphite Dehydrogenase
Structure and Function of Phosphonoacetaldehyde Dehydrogenase: The Missing Link in Phosphonoacetate Formation
CyberTraining: Implementation: Small: Advanced Cyberinfrastructure Training for Next-Generation Neuroscience Learning and Research
REU Site: Summer Research Projects in Neuroscience
RET Site: Research Experiences for Teachers in Neural Engineering
CyberTraining: DSE: Self-Service Training Modules for Data-Intensive Neuroscience Learning and Research
REU Site: Summer Research Projects in Neuroscience
REU Site: Summer Research Projects in Neuroscience
REU Site: Summer Research Projects in Neuroscience
REU Site: Summer Research Projects in Biosystems Modeling and Analysis
Engineering Design in Middle and Secondary Math & Science Education
GOALI-Faculty and Students in Industry: Reduced Order Aeroelastic Dynamic Modeling of Flexible Airplanes
REG: Identification and Control of Dynamic Systems Using Neural and Fuzzy Designs