Area of research
Molecular Biology · Pharmacology
Research interest
Research interests include RNA and protein synthesis mechanisms, CRISPR and Genetic Engineering, RNA modifications and cancer, and Microbial Natural Products and Biosynthesis.
Recessive epistasis of a synonymous mutation confers cucumber domestication through epitranscriptomic regulation
High-precision cytosine base editors by evolving nucleic-acid-recognition hotspots in deaminase
Charting the development and engineering of CRISPR base editors: lessons and inspirations
An adenine base editor variant expands context compatibility
Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing
Assessing and engineering the IscB–ωRNA system for programmed genome editing
Programmed RNA editing with an evolved bacterial adenosine deaminase
Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination
An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity
Structure–Activity Relationships of the Enterococcal Cytolysin
Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
CylA is a sequence-specific protease involved in toxin biosynthesis
Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation
The Enterococcal Cytolysin Synthetase Coevolves with Substrate for Stereoselective Lanthionine Synthesis
The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold
Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage
Substrate control in stereoselective lanthionine biosynthesis
Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS
The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry
Lantibiotics from <i>Geobacillus thermodenitrificans</i>
Structural Characterization of Four Prochlorosins: A Novel Class of Lantipeptides Produced by Planktonic Marine Cyanobacteria