Area of research
Genetics · Molecular Biology
Research interest
Research interests include Virus-based gene therapy research, CRISPR and Genetic Engineering, CAR-T cell therapy research, and RNA Interference and Gene Delivery.
Autologous Ex Vivo Lentiviral Gene Therapy for Adenosine Deaminase Deficiency
Selected Abstracts from the 12th Annual Meeting of the Clinical Immunology Society: 2021 Virtual Annual Meeting: Immune Deficiency and Dysregulation North American Conference
Editing the Sickle Cell Disease Mutation in Human Hematopoietic Stem Cells: Comparison of Endonucleases and Homologous Donor Templates
Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer
Anti-human CD117 antibody-mediated bone marrow niche clearance in nonhuman primates and humanized NSG mice
Site-Specific Gene Editing of Human Hematopoietic Stem Cells for X-Linked Hyper-IgM Syndrome
Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair
CRISPR/Cas9-Mediated Correction of the Sickle Mutation in Human CD34+ cells
Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases
Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells
β-globin gene transfer to human bone marrow for sickle cell disease
Preclinical Demonstration of Lentiviral Vector-mediated Correction of Immunological and Metabolic Abnormalities in Models of Adenosine Deaminase Deficiency
Integrase-defective Lentiviral Vectors as a Delivery Platform for Targeted Modification of Adenosine Deaminase Locus