Area of research
Immunology · Infectious Diseases
Research interest
Research interests include Immunodeficiency and Autoimmune Disorders, Tuberculosis Research and Epidemiology, Mycobacterium research and diagnosis, and T-cell and B-cell Immunology.
Human LY9 governs CD4 <sup>+</sup> T cell IFN-γ immunity to <i>Mycobacterium tuberculosis</i>
Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2
A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
Mendelian Susceptibility to Mycobacterial Disease (MSMD): Clinical, Immunological, and Genetic Features of 22 Patients from 15 Moroccan Kindreds
Human genetic and immunological determinants of critical COVID-19 pneumonia
Studying severe long COVID to understand post-infectious disorders beyond COVID-19
Autoantibodies against type I IFNs in patients with critical influenza pneumonia
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia
Impaired IL-23–dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency
Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency
Human <i>STAT3</i> variants underlie autosomal dominant hyper-IgE syndrome by negative dominance
Biochemically deleterious human <i>NFKB1</i> variants underlie an autosomal dominant form of common variable immunodeficiency
Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria
Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Morocco
Tuberculosis and impaired IL-23–dependent IFN-γ immunity in humans homozygous for a common <i>TYK2</i> missense variant
Human Genetics of Tuberculosis of the Nervous System
Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets
Whole-exome sequencing to analyze population structure, parental inbreeding, and familial linkage
A genome-wide association study of pulmonary tuberculosis in Morocco
Alanine-scanning mutagenesis of human signal transducer and activator of transcription 1 to estimate loss- or gain-of-function variants
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome
Inherited and acquired immunodeficiencies underlying tuberculosis in childhood
Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies
Human genetics of tuberculosis: a long and winding road