Area of research
Immunology · Infectious Diseases
Research interest
Research interests include interferon and immune responses, SARS-CoV-2 and COVID-19 Research, Influenza Virus Research Studies, and Robotic Path Planning Algorithms.
Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA.1 attenuation
Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication
miR-135 protects against atrial fibrillation by suppressing intracellular calcium-mediated NLRP3 inflammasome activation
Actin cytoskeleton remodeling primes RIG-I-like receptor activation
<i>GTF3A</i> mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand <i>RNA5SP141</i>
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
Dysregulation of type I interferon responses in COVID-19
Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity
Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity
MiR-135b protects cardiomyocytes from infarction through restraining the NLRP3/caspase-1/IL-1β pathway