Area of research
Immunology · Molecular Biology
Research interest
Research interests include Immune Cell Function and Interaction, CRISPR and Genetic Engineering, CAR-T cell therapy research, and T-cell and B-cell Immunology.
Integrated epigenetic and genetic programming of primary human T cells
Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy
Site-specific DNA insertion into the human genome with engineered recombinases
Causal modelling of gene effects from regulators to programs to traits
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
Improving prime editing with an endogenous small RNA-binding protein
Bidirectional epigenetic editing reveals hierarchies in gene regulation
Method of moments framework for differential expression analysis of single-cell RNA sequencing data
Central control of dynamic gene circuits governs T cell rest and activation
Gene regulatory network inference from CRISPR perturbations in primary CD4+ T cells elucidates the genomic basis of immune disease
Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes
CRISPR screens decode cancer cell pathways that trigger γδ T cell detection
Base-editing mutagenesis maps alleles to tune human T cell functions
Modular pooled discovery of synthetic knockin sequences to program durable cell therapies
A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
CRISPR activation and interference screens decode stimulation responses in primary human T cells
Obesity alters pathology and treatment response in inflammatory disease
RASA2 ablation in T cells boosts antigen sensitivity and long-term function
High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails
Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies
Systematic discovery and perturbation of regulatory genes in human T cells reveals the architecture of immune networks
CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells
CRISPR–Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells
A functional map of HIV-host interactions in primary human T cells
Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies
Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis
Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering
The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28
XYZeq: Spatially resolved single-cell RNA sequencing reveals expression heterogeneity in the tumor microenvironment