Area of research
Molecular Biology · Immunology
Research interest
Research interests include Ubiquitin and proteasome pathways, interferon and immune responses, PI3K/AKT/mTOR signaling in cancer, and Cancer-related Molecular Pathways.
Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer
Characteristics of and variation in airborne ARGs among urban hospitals and adjacent urban and suburban communities: A metagenomic approach
LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
FAM13A Represses AMPK Activity and Regulates Hepatic Glucose and Lipid Metabolism
AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions
The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168
K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair
Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt
PtdIns(3,4,5) <i>P</i> 3-Dependent Activation of the mTORC2 Kinase Complex
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression
Akt-Mediated Phosphorylation of XLF Impairs Non-Homologous End-Joining DNA Repair
Roles of F-box proteins in cancer
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis