Area of research
Molecular Biology · Pulmonary and Respiratory Medicine
Research interest
Research interests include DNA Repair Mechanisms, RNA Research and Splicing, Prostate Cancer Treatment and Research, and RNA modifications and cancer.
Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation
Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer
Allosteric interactions prime androgen receptor dimerization and activation
Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ERG
Substrate selectivity by the exonuclease Rrp6p
ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis
Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase
Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3
The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome