Area of research
Materials Chemistry · Nutrition and Dietetics
Research interest
Our laboratory studies the chemistry of biology and energy. We advance new concepts in imaging, proteomics, drug discovery, and catalysis by drawing from core disciplines of inorganic, organic, and biological chemistry. For example, we have developed activity-based sensing as a general platform to identify transition metals, reactive oxygen species, and one-carbon units as new classes of single-atom signals for allosteric regulation of protein function. These chemical tools also reveal unique metal and redox disease vulnerabilities as targets for innovative drug discovery efforts to treat neurodegeneration, cancer, and metabolic disorders. Our work in artificial photosynthesis addresses global challenges in climate change.
Peer Review and AI: Your (Human) Opinion Is What Matters.
A nuclear-targeted activity-based sensing probe for ratiometric imaging of formaldehyde reveals endogenous epigenetic contributors to the nuclear formaldehyde pool.
An Activity-Based Sensing Approach to Monitor Nanomaterial-Promoted Changes in Labile Metal Pools in Living Systems.
Chiral methionine oxidation reagents reveal stereospecific proteome modifications
Profiling the proteome-wide selectivity of diverse electrophiles.
A histochemical approach to activity-based copper sensing reveals cuproplasia-dependent vulnerabilities in cancer
A histochemical approach to activity-based copper sensing reveals cuproplasia-dependent vulnerabilities in cancer.
An Alkyne-Directed Cleavage Approach for Activity-Based Cu(I) Sensing Reveals Manganese-Promoted Sensitization of Cuproptosis.
Apoliprotein E-mediated ferroptosis controls cellular proliferation in chronic lymphocytic leukemia.
RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity
An Inverse Electron-Demand Diels-Alder Approach to Selective Activity-Based Sensing of Acetaldehyde in Living Cells.
Author Correction: Oxidative cyclization reagents reveal tryptophan cation-π interactions.
The PBAF chromatin remodeling complex contributes to metal homeostasis through Mtf1 regulation
An Activity-Based Sensing Approach to Monitor Nanomaterial-Promoted Changes in Labile Metal Pools in Living Systems
Repurposing Melatonin in dual-mode for Wilson disease therapy as a Copper Chelator and an antioxidant agent
Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals
Oxidative cyclization reagents reveal tryptophan cation–π interactions
Small-Molecule Fluorescent Probes for Binding- and Activity-Based Sensing of Redox-Active Biological Metals.
Oxidative cyclization reagents reveal tryptophan cation-π interactions.
A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools
Introduction: Fluorescent Probes in Biology.
An Activity-Based Sensing Approach to Multiplex Mapping of Labile Copper Pools by Stimulated Raman Scattering.
A Transfer Hydrogenation Approach to Activity-Based Sensing of Formate in Living Cells.
A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools.
A mitochondrial-targeted activity-based sensing probe for ratiometric imaging of formaldehyde reveals key regulators of the mitochondrial one-carbon pool.
ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer.
Glial <i>swip-10</i> controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis.
Cysteine Rich Intestinal Protein 2 is a copper-responsive regulator of skeletal muscle differentiation and metal homeostasis.
One Carbon to Rule Them All: Formaldehyde is a One-Carbon Signal Connecting One-Carbon Metabolism and Epigenetic Methylation.
Nanomedicine Targeting Cuproplasia in Cancer: Labile Copper Sequestration Using Polydopamine Particles Blocks Tumor Growth <i>In Vivo</i> through Altering Metabolism and Redox Homeostasis.