Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Wnt/β-catenin signaling in development and cancer, Retinal Development and Disorders, Axon Guidance and Neuronal Signaling, and Cancer-related gene regulation.
Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation
Utility of protein–protein binding surfaces composed of anti-parallel alpha-helices and beta-sheets selected by phage display
The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development
A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy
Structure of the RECK CC domain, an evolutionary anomaly
Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development
Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers
Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis
Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood–brain barrier and blood–retina barrier development and maintenance
Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions
Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation
Intramembrane Proteolysis of Astrotactins
Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina
The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation
Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles
Canonical WNT signaling components in vascular development and barrier formation
Cellular Resolution Maps of X Chromosome Inactivation: Implications for Neural Development, Function, and Disease
Partial interchangeability of <i>Fz3</i> and <i>Fz6</i> in tissue polarity signaling for epithelial orientation and axon growth and guidance
Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis
Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons
Norrin/Frizzled4 Signaling in Retinal Vascular Development and Blood Brain Barrier Plasticity
Combinatorial Expression of Brn3 Transcription Factors in Somatosensory Neurons: Genetic and Morphologic Analysis