Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Retinal Development and Disorders, Photoreceptor and optogenetics research, Wnt/β-catenin signaling in development and cancer, and Retinal Diseases and Treatments.
Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation
Utility of protein–protein binding surfaces composed of anti-parallel alpha-helices and beta-sheets selected by phage display
Bacterial meningitis in the early postnatal mouse studied at single-cell resolution
Signaling Pathways in Neurovascular Development
The WNT7A/WNT7B/GPR124/RECK signaling module plays an essential role in mammalian limb development
A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture
A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy
Structure of the RECK CC domain, an evolutionary anomaly
Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus
Roles of HIFs and VEGF in angiogenesis in the retina and brain
Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures
Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution
Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing
Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development
Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers
Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis
Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells
Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood–brain barrier and blood–retina barrier development and maintenance
Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions
Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation
Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura
Peropsin modulates transit of vitamin A from retina to retinal pigment epithelium
Intramembrane Proteolysis of Astrotactins
Epigenomic landscapes of retinal rods and cones
Frizzled Receptors in Development and Disease
Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling
Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain
Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis
Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina
Functional Assembly of Accessory Optic System Circuitry Critical for Compensatory Eye Movements