Stefan G. Sarafianos

A novel corneal epithelial cell culture assay for assessing topical antivirals against herpes simplex virus keratitis.

HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration

The HIV-1 capsid core is an opportunistic nuclear import receptor

Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization

Discovery of Nirmatrelvir Resistance Mutations in SARS-CoV-2 3CLpro: A Computational-Experimental Approach

Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro

Marine Natural Products as Leads against SARS-CoV-2 Infection

Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase

Avoiding Drug Resistance in HIV Reverse Transcriptase

The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

Rotten to the core: antivirals targeting the HIV-1 capsid core

Comparison of anti-SARS-CoV-2 activity and intracellular metabolism of remdesivir and its parent nucleoside

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs

Novel PF74-like small molecules targeting the HIV-1 capsid protein: Balance of potency and metabolic stability

Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules

Novel HIV-1 capsid-targeting small molecules of the PF74 binding site

Chemical profiling of HIV-1 capsid-targeting antiviral PF74

Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus

Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase

4′-Ethynyl-2-fluoro-2′-deoxyadenosine, MK-8591

Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2

6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity

6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H

The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase

Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes

Multiplex single-cell visualization of nucleic acids and protein during HIV infection

Oral Administration of the Nucleoside EFdA (4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine) Provides Rapid Suppression of HIV Viremia in Humanized Mice and Favorable Pharmacokinetic Properties in Mice and the Rhesus Macaque

SAMHD1 Has Differential Impact on the Efficacies of HIV Nucleoside Reverse Transcriptase Inhibitors