Area of research
Virology · Infectious Diseases
Research interest
Research focused on SAMHD1 and Capsid, with related work in Virology, Cell biology, Cypa. Notable publications include 'Structural basis of HIV-1 capsid recognition by PF74 and CPSF6', 'Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core', and 'Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit'.
The HIV-1 capsid core is an opportunistic nuclear import receptor
Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification
SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells
Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core
Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus
Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit
A SAMHD1 mutation associated with Aicardi-Goutières syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans
Structural basis of HIV-1 capsid recognition by PF74 and CPSF6
dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages