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Amanda Heslegrave

UK Dementia Research Institute · GB
Area of research
Physiology · Psychiatry and Mental health
Research interest
Research interests include Alzheimer's disease research and treatments, Dementia and Cognitive Impairment Research, Genetic Neurodegenerative Diseases, and Neuroinflammation and Neurodegeneration Mechanisms.
h-index
56
citations
8,765
works
290
NIH funding
primary concept
email

Recent publications

Novel blood‐based proteomic signatures across multiple neurodegenerative diseases
Alzheimer s & Dementia 2025cited by 20position: middledoi
Serum neurofilament light chain in hereditary transthyretin amyloidosis: validation in real-life practice
Amyloid 2024cited by 20position: middledoi
Poor long-term outcomes and abnormal neurodegeneration biomarkers after military traumatic brain injury: the ADVANCE study
Journal of Neurology Neurosurgery & Psychiatry 2024cited by 15position: middledoi
Active elite rugby participation is associated with altered precentral cortical thickness
Brain Communications 2023cited by 6position: middledoi
Plasma p-tau181, neurofilament light chain and association with cognition in Parkinson’s disease
npj Parkinson s Disease 2022cited by 64position: middledoi
Amyloid processing in <scp>COVID</scp>‐19‐associated neurological syndromes
Journal of Neurochemistry 2022cited by 58position: middledoi
Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study
The Lancet Healthy Longevity 2022cited by 53position: middledoi
Plasma GFAP in presymptomatic and symptomatic familial Alzheimer’s disease: a longitudinal cohort study
Journal of Neurology Neurosurgery & Psychiatry 2022cited by 46position: middledoi
The prognostic significance of early blood neurofilament light chain concentration and magnetic resonance imaging variables in relapse‐onset multiple sclerosis
Brain and Behavior 2022cited by 4position: middledoi
Axonal marker neurofilament light predicts long-term outcomes and progressive neurodegeneration after traumatic brain injury
Science Translational Medicine 2021cited by 193position: middledoi
Transitioning from cerebrospinal fluid to blood tests to facilitate diagnosis and disease monitoring in Alzheimer's disease
Journal of Internal Medicine 2021cited by 105position: middledoi
Serum and cerebrospinal fluid biomarker profiles in acute SARS-CoV-2-associated neurological syndromes
Brain Communications 2021cited by 52position: middledoi
Plasma amyloid-β ratios in autosomal dominant Alzheimer’s disease: the influence of genotype
Brain 2021cited by 34position: middledoi
Brain-derived neurotrophic factor in cerebrospinal fluid and plasma is not a biomarker for Huntington’s disease
Scientific Reports 2021cited by 30position: middledoi
Association of CSF sTREM2, a marker of microglia activation, with cholinergic basal forebrain volume in major depressive disorder
Journal of Affective Disorders 2021cited by 16position: middledoi
A population‐based study of head injury, cognitive function and pathological markers
Annals of Clinical and Translational Neurology 2021cited by 10position: middledoi
Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia
Journal of Neurology Neurosurgery & Psychiatry 2020cited by 193position: middledoi
Plasma phospho-tau181 in presymptomatic and symptomatic familial Alzheimer’s disease: a longitudinal cohort study
Molecular Psychiatry 2020cited by 122position: middledoi
Fluid biomarkers in frontotemporal dementia: past, present and future
Journal of Neurology Neurosurgery & Psychiatry 2020cited by 120position: middledoi
OUP accepted manuscript
Brain 2020cited by 105position: middledoi
Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease
Science Translational Medicine 2020cited by 105position: middledoi
Cerebrospinal Fluid YKL-40 and Chitotriosidase Levels in Frontotemporal Dementia Vary by Clinical, Genetic and Pathological Subtype
Dementia and Geriatric Cognitive Disorders 2020cited by 47position: middledoi
Plasma glial fibrillary acidic protein and neurofilament light chain, but not tau, are biomarkers of sports-related mild traumatic brain injury
Brain Communications 2020cited by 45position: middledoi
The <i>MS4A</i> gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
Science Translational Medicine 2019cited by 281position: middledoi
Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer’s disease
Alzheimer s Research & Therapy 2019cited by 105position: middledoi
Muscle and not neuronal biomarkers correlate with severity in spinal and bulbar muscular atrophy
Neurology 2019cited by 75position: middledoi
<i>PDXK</i> mutations cause polyneuropathy responsive to pyridoxal 5′‐phosphate supplementation
Annals of Neurology 2019cited by 74position: middledoi
Gene replacement therapy in a model of Charcot-Marie-Tooth 4C neuropathy
Brain 2019cited by 63position: middledoi
White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study
NeuroImage Clinical 2019cited by 46position: middledoi
Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers
Alzheimer s Research & Therapy 2019cited by 45position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Henrik Zetterberg · Indian Institute of Science Bangalore33 papers (2015–2025)Kaj Blennow · First Affiliated Hospital of Anhui Medical University13 papers (2018–2025)Nick C. Fox · Hospital Universitario Ramón y Cajal12 papers (2015–2022)Jonathan M. Schott · Sungkyunkwan University9 papers (2015–2021)Ross W. Paterson · University of San Francisco7 papers (2015–2022)Martha Foiani · University of Padua7 papers (2018–2021)Philip S.J. Weston · London School of Hygiene & Tropical Medicine7 papers (2015–2022)Nicholas J. Ashton · Alzheimer's Association7 papers (2019–2025)Ashvini Keshavan · London School of Hygiene & Tropical Medicine7 papers (2018–2021)Jennifer M. Nicholas · University of London6 papers (2015–2021)Carolin Heller · UK Dementia Research Institute5 papers (2018–2020)Antoinette O’Connor · Trinity College Dublin5 papers (2019–2022)Teresa Poole · London School of Hygiene & Tropical Medicine5 papers (2018–2022)Jonathan D. Rohrer · London School of Hygiene & Tropical Medicine5 papers (2018–2020)Natalie S. Ryan · London School of Hygiene & Tropical Medicine4 papers (2019–2022)Jason D. Warren · University College London Hospitals NHS Foundation Trust4 papers (2018–2020)Simon Mead · University of London3 papers (2019–2021)Chris Frost · London School of Hygiene & Tropical Medicine3 papers (2019–2021)Rachael I. Scahill · Huntington's Disease Association3 papers (2018–2021)James M. Polke · National Hospital for Neurology and Neurosurgery3 papers (2020–2022)