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Julian P. Whitelegge

University of California, Los Angeles · US
Area of research
Molecular Biology · Spectroscopy
Research interest
Research interests include Photosynthetic Processes and Mechanisms, Advanced Proteomics Techniques and Applications, Mass Spectrometry Techniques and Applications, and Metabolomics and Mass Spectrometry Studies.
h-index
72
citations
19,581
works
441
NIH funding
primary concept
email

Recent publications

Discovery of a small molecule secreted clusterin enhancer that improves memory in Alzheimer’s disease mice
npj Drug Discovery. 2025cited by 5position: middledoi
Cryo-EM analysis of Pseudomonas phage Pa193 structural components
Communications Biology 2024cited by 9position: middledoi
Therapy of autoimmune inflammation in sporadic amyotrophic lateral sclerosis: Dimethyl fumarate and H‐151 downregulate inflammatory cytokines in the <scp>cGAS‐STING</scp> pathway
The FASEB Journal 2023cited by 32position: middledoi
A Highly Ordered Nitroxide Side Chain for Distance Mapping and Monitoring Slow Structural Fluctuations in Proteins
Applied Magnetic Resonance 2023cited by 12position: middledoi
CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization
Nature 2022cited by 55position: middledoi
Improved zebra finch brain transcriptome identifies novel proteins with sex differences
Gene 2022cited by 3position: middledoi
Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury
Cell 2020cited by 210position: middledoi
Best practices and benchmarks for intact protein analysis for top-down mass spectrometry
Nature Methods 2019cited by 386position: middledoi
Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA
Nature Medicine 2018cited by 267position: middledoi
The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle
Molecular Metabolism 2018cited by 121position: middledoi
Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition
Proceedings of the National Academy of Sciences 2018cited by 96position: middledoi
Proteomics of Bronchoalveolar Lavage Fluid Reveals a Lung Oxidative Stress Response in Murine Herpesvirus-68 Infection
Viruses 2018cited by 3position: middledoi
Proteomics of Bronchoalveolar Lavage Fluid Reveals a Lung Oxidative Stress Response in Murine Herpesvirus-68 Infection
Preprints.org 2018cited by 1position: middledoi
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence
Neuron 2017cited by 763position: middledoi
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models
Gastroenterology 2017cited by 416position: middledoi
Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1
Journal of Biological Chemistry 2017cited by 78position: middledoi
ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways
Nature Communications 2017cited by 70position: middledoi
RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs
Journal of Clinical Investigation 2017cited by 46position: middledoi
Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females
Science Translational Medicine 2016cited by 257position: middledoi
Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis
Nature 2016cited by 213position: middledoi
Structure of the toxic core of α-synuclein from invisible crystals
Nature 2015cited by 624position: middledoi
Uncovering the Mechanism of Aggregation of Human Transthyretin
Journal of Biological Chemistry 2015cited by 158position: middledoi
Ketones block amyloid entry and improve cognition in an Alzheimer's model
Neurobiology of Aging 2015cited by 150position: middledoi
Septin Dynamics Are Essential for Exocytosis
Journal of Biological Chemistry 2015cited by 84position: middledoi
Cyclic Rhamnosylated Elongation Factor P Establishes Antibiotic Resistance in Pseudomonas aeruginosa
mBio 2015cited by 72position: middledoi
The Disulfide Bond, but Not Zinc or Dimerization, Controls Initiation and Seeded Growth in Amyotrophic Lateral Sclerosis-linked Cu,Zn Superoxide Dismutase (SOD1) Fibrillation
Journal of Biological Chemistry 2015cited by 63position: lastdoi
Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis
Cell Cycle 2015cited by 49position: middledoi
High CO<sub>2</sub> Leads to Na,K-ATPase Endocytosis via c-Jun Amino-Terminal Kinase-Induced LMO7b Phosphorylation
Molecular and Cellular Biology 2015cited by 35position: middledoi
Formation of Amyloid Fibers by Monomeric Light Chain Variable Domains
Journal of Biological Chemistry 2014cited by 56position: middledoi
Mammalian Protein Arginine Methyltransferase 7 (PRMT7) Specifically Targets RXR Sites in Lysine- and Arginine-rich Regions
Journal of Biological Chemistry 2013cited by 170position: middledoi

Grants

I-Corps: A cloud-based searchable catalog to link geographically and population diverse patient genomic, phenotypic and clinical data
NSF2029812$50,0002020–2021PIRePORTER

Frequent collaborators

David Eisenberg · UCLA Medical Center6 papers (2012–2018)Whitaker Cohn · University of Southern California5 papers (2015–2025)M.R. Sawaya · UCLA Medical Center4 papers (2012–2015)Kym F. Faull · University of California, Los Angeles3 papers (2012–2017)Duilio Cascio · University of California, Los Angeles3 papers (2012–2015)Joseph Capri · University of California, Los Angeles3 papers (2015–2017)Tamer Sallam · University of California, Los Angeles3 papers (2016–2018)Peter Tontonoz · University of California, Los Angeles3 papers (2016–2018)Christopher M. Ryan · University of Pittsburgh3 papers (2012–2015)Lisa M. Johnson · University of Minnesota2 papers (2015–2015)Joan Selverstone Valentine · University of California, Los Angeles2 papers (2013–2015)Cynthia Hong · Merck & Co., Inc., Rahway, NJ, USA (United States)2 papers (2016–2018)Duilio Cascio · UCLA Medical Center2 papers (2015–2023)Lorena Saelices · Southwestern Medical Center2 papers (2015–2018)Lin Jiang · South China Agricultural University2 papers (2015–2015)Olga Vagin · VA West Los Angeles Medical Center2 papers (2015–2015)Meytal Landau · University Medical Center Hamburg-Eppendorf2 papers (2012–2014)Aldons J. Lusis · ABT Molecular Imaging (United States)2 papers (2018–2018)David Casero · Cedars-Sinai Smidt Heart Institute2 papers (2016–2018)Jaspreet Sandhu · Howard Hughes Medical Institute2 papers (2016–2018)