Area of research
Molecular Biology · Radiology, Nuclear Medicine and Imaging
Research interest
Research interests include Protein Tyrosine Phosphatases, Protein Structure and Dynamics, Monoclonal and Polyclonal Antibodies Research, and Protein Kinase Regulation and GTPase Signaling.
The pathogenic T42A mutation in SHP2 rewires the interaction specificity of its N-terminal regulatory domain
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks
Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase
Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases
Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane
Molecular basis for multimerization in the activation of the epidermal growth factor receptor
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor
Protein collapse driven against solvation free energy without <scp>H</scp>‐bonds