Area of research
Molecular Biology · Oncology
Research interest
Research interests include DNA Repair Mechanisms, PARP inhibition in cancer therapy, DNA and Nucleic Acid Chemistry, and Cancer-related Molecular Pathways.
Virtual fragment screening for DNA repair inhibitors in vast chemical space
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing
Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair
DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair
Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress