Area of research
Molecular Biology · Hematology
Research interest
Research interests include DNA Repair Mechanisms, Biochemical and Molecular Research, Acute Myeloid Leukemia Research, and Folate and B Vitamins Research.
Virtual fragment screening for DNA repair inhibitors in vast chemical space
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors
Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Validation and development of MTH1 inhibitors for treatment of cancer
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool