Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include DNA Repair Mechanisms, Biochemical and Molecular Research, Cancer, Hypoxia, and Metabolism, and RNA modifications and cancer.
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function
The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform‐Selective Inhibitors
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses
Structural basis of inhibition of the human serine hydroxymethyltransferase <scp>SHMT</scp>2 by antifolate drugs
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Validation and development of MTH1 inhibitors for treatment of cancer
Processing of protein ADP-ribosylation by Nudix hydrolases
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy