Area of research
Materials Chemistry · Oncology
Research interest
Research interests include Cytokine Signaling Pathways and Interactions, Crystallization and Solubility Studies, X-ray Diffraction in Crystallography, and Cancer Mechanisms and Therapy.
Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases
The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase
NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Oncogenic Kinase Cascades Induce Molecular Mechanisms That Protect Leukemic Cell Models from Lethal Effects of De Novo dNTP Synthesis Inhibition
Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia
Design, Optimization, and Pre-Clinical Evaluation of Direct, Mechanism-Based STAT3 Inhibitors for Treating Myeloid Disorders
STAT3 activity is necessary and sufficient for the development of immune‐mediated myocarditis in mice and promotes progression to dilated cardiomyopathy