Area of research
Molecular Biology · Physiology
Research interest
Research interests include Ion Transport and Channel Regulation, Ion channel regulation and function, Nitric Oxide and Endothelin Effects, and Electrolyte and hormonal disorders.
Effects of proximal tubule NBCe1-A deletion on collecting duct intercalated cell responses to hypokalemia.
Pendrin is upregulated by corticosterone and participates in its pressor response.
Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase.
Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect
Dietary anions control potassium excretion: it is more than a poorly absorbable anion effect.
Pendrin regulation is prioritized by anion in high-potassium diets.
Bicarbonate is the primary inducer of KCC3a expression in renal cortical B-type intercalated cells.
The proximal tubule through an NBCe1-dependent mechanism regulates collecting duct phenotypic and remodeling responses to acidosis.
Regulation of Blood Pressure and Salt Balance By Pendrin-Positive Intercalated Cells: Donald Seldin Lecture 2020.
Pendrin-null mice develop severe hypokalemia following dietary Na<sup>+</sup> and K<sup>+</sup> restriction: role of ENaC.
Proinflammatory P2Y14 receptor inhibition protects against ischemic acute kidney injury in mice
The Renal Physiology of Pendrin-Positive Intercalated Cells
Aldosterone Regulates Pendrin and Epithelial Sodium Channel Activity through Intercalated Cell Mineralocorticoid Receptor–Dependent and –Independent Mechanisms over a Wide Range in Serum Potassium
The Role of Intercalated Cell Nedd4–2 in BP Regulation, Ion Transport, and Transporter Expression
Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq
Integrated compensatory network is activated in the absence of NCC phosphorylation
The Role of Pendrin in Renal Physiology
Pendrin gene ablation alters ENaC subcellular distribution and open probability
The role of pendrin in blood pressure regulation
Pendrin localizes to the adrenal medulla and modulates catecholamine release
Epithelial Anion Transporter Pendrin Contributes to Inflammatory Lung Pathology in Mouse Models of Bordetella pertussis Infection
Cortical distal nephron Cl<sup>−</sup>transport in volume homeostasis and blood pressure regulation
ENaC inhibition stimulates Cl <sup>−</sup> secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism