Area of research
Molecular Biology · Global and Planetary Change
Research interest
Research interests include Amphibian and Reptile Biology, Phytochemical compounds biological activities, RNA and protein synthesis mechanisms, and Species Distribution and Climate Change.
A chemical screen identifies structurally diverse metal chelators with activity against the fungal pathogen <i>Candida albicans</i>
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling
Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication
Defining and navigating macrocycle chemical space
Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity
Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis
Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris
Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris
Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors
Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors
Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors
Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas
Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space
Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma
Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B: Selective Excited‐State Intramolecular Proton‐Transfer Photocycloaddition
Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism
A Novel Class of Small Molecule Compounds that Inhibit Hepatitis C Virus Infection by Targeting the Prohibitin-CRaf Pathway