Area of research
Ophthalmology · Molecular Biology
Research interest
Research interests include Ocular Oncology and Treatments, Retinal Development and Disorders, Ubiquitin and proteasome pathways, and Cancer-related Molecular Pathways.
Early genetic evolution of driver mutations in uveal melanoma
15-Gene Expression Profile and <i>PRAME</i> as Integrated Prognostic Test for Uveal Melanoma: First Report of Collaborative Ocular Oncology Group Study No. 2 (COOG2.1)
Phase II multi-center study of adjuvant nivolumab in combination with ipilimumab in patients with high-risk uveal melanoma (HCRN MEL17-309).
Identification of targetable epigenetic vulnerabilities for uveal melanoma
Advances in the clinical management of uveal melanoma
PRAME induces genomic instability in uveal melanoma
Retinoblastoma Outcomes in the Americas: A Prospective Analysis of 491 Children With Retinoblastoma From 23 American Countries
Activation of NFAT by HGF and IGF-1 via ARF6 and its effector ASAP1 promotes uveal melanoma metastasis
BAP1 Loss Promotes Suppressive Tumor Immune Microenvironment via Upregulation of PROS1 in Class 2 Uveal Melanomas
Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
Adjuvant crizotinib in high-risk uveal melanoma following definitive therapy
Translational Epidemiology: An Integrative Approach to Determine the Interplay Between Genetic Ancestry and Neighborhood Socioeconomic Status on Triple Negative Breast Cancer
Early Mechanisms of Chemoresistance in Retinoblastoma
RB1 loss triggers dependence on ESRRG in retinoblastoma
HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma
Uphyloplot2: visualizing phylogenetic trees from single-cell RNA-seq data
Functional impact of titin (TTN) mutations in ocular surface squamous neoplasia
The AMP‐dependent kinase pathway is upregulated in <i>BAP1</i> mutant uveal melanoma
Gain of Chromosome 6p Correlates with Severe Anaplasia, Cellular Hyperchromasia, and Extraocular Spread of Retinoblastoma
NCT04552223: A phase II study of nivolumab plus BMS-986016 (relatlimab) in patients with metastatic uveal melanoma (UM) (CA224-094).
Multimodal Imaging in the Diagnosis of Exophytic Juxtapapillary Retinal Capillary Hemangioblastoma
Structural Protein Analysis of Driver Gene Mutations in Conjunctival Melanoma
Multiregional genetic evolution of metastatic uveal melanoma
Single-cell analysis reveals new evolutionary complexity in uveal melanoma
Biological Mechanisms and Clinical Significance of <i>BAP1</i> Mutations in Human Cancer
Single-cell analysis of olfactory neurogenesis and differentiation in adult humans
BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors
Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma
A novel cardiomyogenic role for Isl1 <sup>+</sup> neural crest cells in the inflow tract
Impact of Genetic Ancestry on Prognostic Biomarkers in Uveal Melanoma