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J. William Harbour

The University of Texas Southwestern Medical Center · US
🔎 Find collaborators in Ophthalmology · Molecular Biology →
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Area of research
Ophthalmology · Molecular Biology
Research interest
Research interests include Ocular Oncology and Treatments, Retinal Development and Disorders, Ubiquitin and proteasome pathways, and Cancer-related Molecular Pathways.
h-index
70
citations
20,922
works
462
NIH funding
primary concept
email

Recent publications

Early genetic evolution of driver mutations in uveal melanoma
Nature Communications 2025cited by 2position: lastdoi
15-Gene Expression Profile and <i>PRAME</i> as Integrated Prognostic Test for Uveal Melanoma: First Report of Collaborative Ocular Oncology Group Study No. 2 (COOG2.1)
Journal of Clinical Oncology 2024cited by 51position: firstdoi
Phase II multi-center study of adjuvant nivolumab in combination with ipilimumab in patients with high-risk uveal melanoma (HCRN MEL17-309).
Journal of Clinical Oncology 2024cited by 6position: middledoi
Identification of targetable epigenetic vulnerabilities for uveal melanoma
2024cited by 1position: contributordoi
Advances in the clinical management of uveal melanoma
Nature Reviews Clinical Oncology 2023cited by 267position: middledoi
PRAME induces genomic instability in uveal melanoma
Oncogene 2023cited by 25position: lastdoi
Retinoblastoma Outcomes in the Americas: A Prospective Analysis of 491 Children With Retinoblastoma From 23 American Countries
American Journal of Ophthalmology 2023cited by 15position: middledoi
Activation of NFAT by HGF and IGF-1 via ARF6 and its effector ASAP1 promotes uveal melanoma metastasis
Oncogene 2023cited by 10position: middledoi
BAP1 Loss Promotes Suppressive Tumor Immune Microenvironment via Upregulation of PROS1 in Class 2 Uveal Melanomas
Cancers 2022cited by 37position: lastdoi
Multi-omics Profiling Shows BAP1 Loss Is Associated with Upregulated Cell Adhesion Molecules in Uveal Melanoma
Molecular Cancer Research 2022cited by 29position: middledoi
Adjuvant crizotinib in high-risk uveal melanoma following definitive therapy
Frontiers in Oncology 2022cited by 24position: middledoi
Translational Epidemiology: An Integrative Approach to Determine the Interplay Between Genetic Ancestry and Neighborhood Socioeconomic Status on Triple Negative Breast Cancer
Annals of Surgery 2022cited by 23position: middledoi
Early Mechanisms of Chemoresistance in Retinoblastoma
Cancers 2022cited by 21position: lastdoi
RB1 loss triggers dependence on ESRRG in retinoblastoma
Science Advances 2022cited by 20position: lastdoi
HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma
Cancer Gene Therapy 2022cited by 10position: middledoi
Uphyloplot2: visualizing phylogenetic trees from single-cell RNA-seq data
BMC Genomics 2021cited by 41position: lastdoi
Functional impact of titin (TTN) mutations in ocular surface squamous neoplasia
International Journal of Biological Macromolecules 2021cited by 18position: lastdoi
The AMP‐dependent kinase pathway is upregulated in <i>BAP1</i> mutant uveal melanoma
Pigment Cell & Melanoma Research 2021cited by 15position: middledoi
Gain of Chromosome 6p Correlates with Severe Anaplasia, Cellular Hyperchromasia, and Extraocular Spread of Retinoblastoma
Ophthalmology Science 2021cited by 15position: middledoi
NCT04552223: A phase II study of nivolumab plus BMS-986016 (relatlimab) in patients with metastatic uveal melanoma (UM) (CA224-094).
Journal of Clinical Oncology 2021cited by 15position: lastdoi
Multimodal Imaging in the Diagnosis of Exophytic Juxtapapillary Retinal Capillary Hemangioblastoma
American Journal of Ophthalmology 2021cited by 14position: lastdoi
Structural Protein Analysis of Driver Gene Mutations in Conjunctival Melanoma
Genes 2021cited by 12position: middledoi
Multiregional genetic evolution of metastatic uveal melanoma
npj Genomic Medicine 2021cited by 11position: middledoi
Single-cell analysis reveals new evolutionary complexity in uveal melanoma
Nature Communications 2020cited by 476position: lastdoi
Biological Mechanisms and Clinical Significance of <i>BAP1</i> Mutations in Human Cancer
Cancer Discovery 2020cited by 283position: middledoi
Single-cell analysis of olfactory neurogenesis and differentiation in adult humans
Nature Neuroscience 2020cited by 249position: middledoi
BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors
Oncogene 2020cited by 48position: middledoi
Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma
Molecular Cancer Research 2020cited by 35position: lastdoi
A novel cardiomyogenic role for Isl1 <sup>+</sup> neural crest cells in the inflow tract
Science Advances 2020cited by 20position: middledoi
Impact of Genetic Ancestry on Prognostic Biomarkers in Uveal Melanoma
Cancers 2020cited by 10position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

Michael Durante · University of Miami Health System13 papers (2016–2023)Matthew G. Field · Minnesota Eye Consultants11 papers (2014–2023)Christina L. Decatur · University of Miami10 papers (2016–2024)Daniel A. Rodriguez · University of California, Berkeley8 papers (2019–2023)A. Bowcock · Human Genome Sciences (United States)7 papers (2013–2018)Jeffim N. Kuznetsoff · University of Miami6 papers (2020–2023)Zélia M. Corrêa · University of Miami6 papers (2012–2023)Richard D. Carvajal · Northwell Health4 papers (2021–2024)Margaret I. Sanchez · University of Miami4 papers (2020–2023) · 4 papers (2012–2013) · 4 papers (2012–2013)Anthony Cruz · University of Tennessee Health Science Center4 papers (2021–2023)Timothy J. Purwin · Drexel University3 papers (2020–2022)Peng Zhang · The University of Texas at San Antonio Health Science Center3 papers (2017–2018)Hui Yang · The University of Texas at San Antonio Health Science Center3 papers (2017–2018)Ying Guo · Yunnan University3 papers (2017–2018)Feng‐Chun Yang · The University of Texas at San Antonio Health Science Center3 papers (2017–2018)Jeffim N. Kuznetsov · Sylvester Comprehensive Cancer Center3 papers (2016–2020)Dawn A. Owens · Southeastern University3 papers (2019–2022)Manuel Paez-Escamilla · University of Miami3 papers (2017–2018)
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