Area of research
Immunology · Molecular Biology
Research interest
Research interests include Immune Cell Function and Interaction, T-cell and B-cell Immunology, Cancer, Hypoxia, and Metabolism, and Epigenetics and DNA Methylation.
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted
The XCL1–XCR1 axis supports intestinal tissue residency and antitumor immunity
CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8+ T cell formation
Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer
Metabolic programs of T cell tissue residency empower tumour immunity
Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62
CD8+ T cell metabolism in infection and cancer
Supporting the Next Generation of Scientists to Lead Cancer Immunology Research
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population
Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population
NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly
Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer
ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells
p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer
Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis