Area of research
Radiology, Nuclear Medicine and Imaging · Molecular Biology
Research interest
Research interests include Monoclonal and Polyclonal Antibodies Research, Virus-based gene therapy research, RNA Interference and Gene Delivery, and Glycosylation and Glycoproteins Research.
Complete inhibition of β-tryptase by tetramer dissociation and active site allostery due to a single antibody residue
Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling
Preclinical and translational pharmacology of afucosylated anti‐CCR8 antibody for depletion of tumour‐infiltrating regulatory T cells
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors
Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8
Structure of the core human NADPH oxidase NOX2
Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma
Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action
Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W
Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge
Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma
A targeted boost-and-sort immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies
Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
An Improved Single-Chain Fab Platform for Efficient Display and Recombinant Expression
Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation
Nature-inspired design of motif-specific antibody scaffolds