Area of research
Molecular Biology · Genetics
Research interest
Research focused on Enhancer and Computational biology, with related work in Transcription factor, Genetics, Microevolution. Notable publications include 'Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations', 'Detecting Natural Selection in Genomic Data', and 'Systematic mapping of functional enhancer–promoter connections with CRISPR interference'.
Compatibility rules of human enhancer and promoter sequences
Inferring gene regulation from stochastic transcriptional variation across single cells at steady state
Compatibility logic of human enhancer and promoter sequences
Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations
Activity-by-Contact model of enhancer specificity from thousands of CRISPR perturbations
Positional specificity of different transcription factor classes within enhancers
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
Systematic dissection of genomic features determining transcription factor binding and enhancer function
Systematic mapping of functional enhancer–promoter connections with CRISPR interference
RNA-RNA Interactions Enable Specific Targeting of Noncoding RNAs to Nascent Pre-mRNAs and Chromatin Sites
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel
Detecting Natural Selection in Genomic Data
Identifying Recent Adaptations in Large-Scale Genomic Data