Area of research
Molecular Biology · Hematology
Research interest
Research interests include Acute Myeloid Leukemia Research, Epigenetics and DNA Methylation, Histone Deacetylase Inhibitors Research, and RNA Interference and Gene Delivery.
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
A second space age spanning omics, platforms and medicine across orbits
Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight
Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia
Measurable residual disease by flow cytometry in acute myeloid leukemia is prognostic, independent of genomic profiling
Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence
DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation
Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia
Temporal Telomere and DNA Damage Responses in the Space Radiation Environment
Multi-omic, Single-Cell, and Biochemical Profiles of Astronauts Guide Pharmacological Strategies for Returning to Gravity
Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development
Clonal Hematopoiesis Before, During, and After Human Spaceflight
Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
CD97 is a critical regulator of acute myeloid leukemia stem cell function
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
CD99 is a therapeutic target on disease stem cells in myeloid malignancies
Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers
Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in <i>IDH2</i> - and <i>TET2</i> -Mutant Acute Myeloid Leukemia
Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia
DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling
Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
A Hybrid Mechanism of Action for BCL6 in B Cells Defined by Formation of Functionally Distinct Complexes at Enhancers and Promoters
An optimized algorithm for detecting and annotating regional differential methylation
Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment
methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles
Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia