Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Receptor Mechanisms and Signaling, Neuropeptides and Animal Physiology, Cellular transport and secretion, and Lipid Membrane Structure and Behavior.
Intersection of GPCR trafficking and cAMP signaling at endomembranes
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
Profiling the proximal proteome of the activated μ-opioid receptor
Selective targeting of mu opioid receptors to primary cilia
A proximity proteomics pipeline with improved reproducibility and throughput
β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR
Gαs is dispensable for β-arrestin coupling but dictates GRK selectivity and is predominant for gene expression regulation by β2-adrenergic receptor
Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics
State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides
Endocytic trafficking determines cellular tolerance of presynaptic opioid signaling
A Molecular Landscape of Mouse Hippocampal Neuromodulation
Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis
Endosomal cAMP production broadly impacts the cellular phosphoproteome
An expanded palette of dopamine sensors for multiplex imaging in vivo
G protein-regulated endocytic trafficking of adenylyl cyclase type 9
Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells
Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators
A Discrete Presynaptic Vesicle Cycle for Neuromodulator Receptors
Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors
A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action
Subcellular Organization of GPCR Signaling
Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity
Catalytic activation of β-arrestin by GPCRs
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders
When trafficking and signaling mix: How subcellular location shapes G protein‐coupled receptor activation of heterotrimeric G proteins
Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras
An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells
Functional selectivity of GPCR-directed drug action through location bias
Genetic evidence that β-arrestins are dispensable for the initiation of β <sub>2</sub> -adrenergic receptor signaling to ERK
Time-gated detection of protein-protein interactions with transcriptional readout