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Brian O’Rourke

Johns Hopkins University · US
Area of research
Molecular Biology · Cardiology and Cardiovascular Medicine
Research interest
Research interests include Mitochondrial Function and Pathology, Cardiac electrophysiology and arrhythmias, Cardiac Ischemia and Reperfusion, and Ion channel regulation and function.
h-index
93
citations
28,665
works
447
NIH funding
primary concept
email

Recent publications

Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling
Biophysical Journal 2023cited by 2position: middledoi
Myocardial brain-derived neurotrophic factor regulates cardiac bioenergetics through the transcription factor Yin Yang 1
Cardiovascular Research 2022cited by 44position: middledoi
Hydropersulfides (RSSH) Outperform Post-Conditioning and Other Reactive Sulfur Species in Limiting Ischemia–Reperfusion Injury in the Isolated Mouse Heart
Antioxidants 2022cited by 24position: middledoi
Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy
Science Translational Medicine 2021cited by 90position: middledoi
The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis
Science Advances 2021cited by 40position: middledoi
Mitochondrial DNA copy number can influence mortality and cardiovascular disease via methylation of nuclear DNA CpGs
Genome Medicine 2020cited by 120position: middledoi
Mitochondrial DNA copy number and incident atrial fibrillation
BMC Medicine 2020cited by 39position: middledoi
Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP
Journal of Molecular and Cellular Cardiology 2020cited by 35position: lastdoi
<i>TNNT2</i> mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction
Proceedings of the National Academy of Sciences 2020cited by 29position: middledoi
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK
Cell Reports 2019cited by 424position: middledoi
Unlocking the Secrets of Mitochondria in the Cardiovascular System
Circulation 2019cited by 135position: middledoi
Precisely Control Mitochondria with Light to Manipulate Cell Fate Decision
Biophysical Journal 2019cited by 32position: middledoi
Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure
Circulation Research 2018cited by 239position: lastdoi
Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models
JCI Insight 2018cited by 40position: middledoi
Fidgetin-Like 2 siRNA Enhances the Wound Healing Capability of a Surfactant Polymer Dressing
Advances in Wound Care 2018cited by 35position: firstdoi
Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy
Cell Reports 2017cited by 103position: middledoi
53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis
eLife 2016cited by 224position: middledoi
Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts
Journal of Proteome Research 2016cited by 83position: middledoi
Mitochondrial redox and pH signaling occurs in axonal and synaptic organelle clusters
Scientific Reports 2016cited by 27position: middledoi
Impaired mitochondrial network excitability in failing guinea-pig cardiomyocytes
Cardiovascular Research 2015cited by 69position: middledoi
Inhibiting Mitochondrial Na <sup>+</sup> /Ca <sup>2+</sup> Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure
Circulation Research 2014cited by 183position: lastdoi
Effects of Regional Mitochondrial Depolarization on Electrical Propagation
Circulation Arrhythmia and Electrophysiology 2014cited by 63position: lastdoi
Mitochondria-derived ROS bursts disturb Ca<sup>2+</sup> cycling and induce abnormal automaticity in guinea pig cardiomyocytes: a theoretical study
American Journal of Physiology-Heart and Circulatory Physiology 2014cited by 54position: middledoi
Redox-Optimized ROS Balance and the relationship between mitochondrial respiration and ROS
Biochimica et Biophysica Acta (BBA) - Bioenergetics 2013cited by 153position: middledoi
HNO Enhances SERCA2a Activity and Cardiomyocyte Function by Promoting Redox-Dependent Phospholamban Oligomerization
Antioxidants and Redox Signaling 2013cited by 78position: middledoi
Endocardial Cells Form the Coronary Arteries by Angiogenesis through Myocardial-Endocardial VEGF Signaling
Cell 2012cited by 389position: middledoi
Bax regulates primary necrosis through mitochondrial dynamics
Proceedings of the National Academy of Sciences 2012cited by 287position: middledoi
Glutathione/thioredoxin systems modulate mitochondrial H2O2 emission: An experimental-computational study
The Journal of General Physiology 2012cited by 192position: middledoi
Mitochondrial ROMK Channel Is a Molecular Component of MitoK <sub>ATP</sub>
Circulation Research 2012cited by 191position: lastdoi
Cardiac mitochondrial network excitability: insights from computational analysis
American Journal of Physiology-Heart and Circulatory Physiology 2012cited by 37position: lastdoi

Grants

No grants ingested yet.

Frequent collaborators

Ting Liu · Johns Hopkins University7 papers (2014–2020)Lufang Zhou · University of Alabama at Birmingham6 papers (2012–2019)Nazareno Paolocci · University of Alabama at Birmingham5 papers (2012–2022)Miguel A. Aon · Johns Hopkins Medicine5 papers (2012–2023)D. Brian Foster · Wake Forest University4 papers (2012–2020)David A. Kass · University of Baltimore3 papers (2013–2022)Agnieszka Sidor · University of Glasgow3 papers (2012–2018)Sonia Cortassa · University of Alabama at Birmingham3 papers (2012–2014)An‐Chi Wei · National Taiwan University3 papers (2012–2022)John Lane · University of Minnesota, Twin Cities2 papers (2020–2020)Antonis A. Armoundas · Intas Pharmaceuticals (India)2 papers (2016–2023)Eliseo Güallar · McMaster University2 papers (2020–2020)Christina A. Castellani · Johns Hopkins Medicine2 papers (2020–2020)Traci M. Bartz · University of Washington2 papers (2020–2020)Theodore P. Abraham · Baim Institute for Clinical Research2 papers (2014–2018)Dong I. Lee · Johns Hopkins University2 papers (2013–2017)Vidhya Sivakumaran · Virginia Tech2 papers (2012–2013)Felix T. Kurz · University of Geneva2 papers (2016–2023)Nathan Pankratz · University of Minnesota2 papers (2020–2020)Deeptankar DeMazumder · University of Virginia2 papers (2014–2018)