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Juan Manuel Sepúlveda-Sánchez

Research Institute Hospital 12 de Octubre ·
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Area of research
Genetics · Pulmonary and Respiratory Medicine
Research interest
Research interests include Glioma Diagnosis and Treatment, Brain Metastases and Treatment, Lung Cancer Treatments and Mutations, and Colorectal Cancer Treatments and Studies.
h-index
41
citations
7,974
works
444
NIH funding
primary concept
Medicine
email

Recent publications

Vorasidenib in IDH1-mutant or IDH2-mutant low-grade glioma (INDIGO): secondary and exploratory endpoints from a randomised, double-blind, placebo-controlled, phase 3 trial
The Lancet Oncology 2025cited by 11position: middledoi
10204-CS-21 Exploratory analyses from the INDIGO study on the mechanism of seizure control by vorasidenib through tumor volume reduction
Neuro-Oncology Advances 2025cited by 1position: middledoi
A phase 2 randomized trial with autologous polyclonal expanded regulatory T cells in children with new-onset type 1 diabetes
Science Translational Medicine 2024cited by 60position: middledoi
Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial
Neuro-Oncology 2024cited by 43position: middledoi
3D volume growth rate evaluation in the EORTC-BTG-1320 clinical trial for recurrent WHO grade 2 and 3 meningiomas
Neuro-Oncology 2024cited by 7position: middledoi
CTNI-53. A GLOBAL, RANDOMIZED, DOUBLE-BLINDED, PHASE 3 STUDY OF VORASIDENIB VERSUS PLACEBO IN PATIENTS WITH ADULT-TYPE DIFFUSE GLIOMA WITH AN IDH1/2 MUTATION (INDIGO): UPDATED EFFICACY RESULTS
Neuro-Oncology 2024cited by 7position: middledoi
A Randomized, Double-blind, Phase 3 Study of Vorasidenib Versus Placebo in Patients with Mutant IDH1/2 Diffuse Glioma (INDIGO): Analysis of Health-related Quality of Life, Neurocognition and Seizures (PL5.003)
Neurology 2024cited by 6position: middledoi
10311- ACT-19 A GLOBAL, RANDOMIZED, DOUBLE-BLINDED, PHASE 3 STUDY OF VORASIDENIB VERSUS PLACEBO IN PATIENTS WITH ADULT-TYPE DIFFUSE GLIOMA WITH AN IDH1/2 MUTATION (INDIGO): UPDATED EFFICACY RESULTS
Neuro-Oncology Advances 2024cited by 3position: middledoi
Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma
New England Journal of Medicine 2023cited by 690position: middledoi
QOL-26. A RANDOMIZED, DOUBLE-BLIND PHASE 3 STUDY OF VORASIDENIB VS PLACEBO IN PATIENTS WITH MUTANT <i>IDH1/2</i>DIFFUSE GLIOMA (INDIGO): ANALYSIS OF HEALTH-RELATED QUALITY OF LIFE, NEUROCOGNITION AND SEIZURES
Neuro-Oncology 2023cited by 19position: middledoi
LTBK-06. IMPACT OF VORASIDENIB TREATMENT ON MUTANT <i>IDH1</i> OR <i>IDH2</i> DIFFUSE GLIOMA TUMOR GROWTH RATE: RESULTS FROM THE RANDOMIZED, DOUBLE-BLIND, PHASE 3 INDIGO STUDY
Neuro-Oncology 2023cited by 18position: middledoi
3D volume growth rate evaluation in the EORTC-BTG-1320 clinical trial for recurrent WHO grade 2 and 3 meningiomas.
Journal of Clinical Oncology 2023cited by 2position: middledoi
498O INDIGO: A randomized, double-blinded, phase III study of vorasidenib versus placebo in IDH1 or IDH2 low-grade glioma
Annals of Oncology 2023cited by 2position: middledoi
Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated <i>MGMT</i> promoter: An international randomized phase III trial
Neuro-Oncology 2022cited by 466position: middledoi
Efficacy and Safety of Telaglenastat Plus Cabozantinib vs Placebo Plus Cabozantinib in Patients With Advanced Renal Cell Carcinoma
JAMA Oncology 2022cited by 139position: middledoi
Infigratinib in Patients with Recurrent Gliomas and FGFR Alterations: A Multicenter Phase II Study
Zurich Open Repository and Archive (University of Zurich) 2022cited by 76position: middledoi
Trotabresib (CC-90010) in combination with adjuvant temozolomide or concomitant temozolomide plus radiotherapy in patients with newly diagnosed glioblastoma
Neuro-Oncology Advances 2022cited by 17position: lastdoi
Trabectedin for recurrent WHO grade 2 or 3 meningioma: A randomized phase II study of the EORTC Brain Tumor Group (EORTC-1320-BTG)
Neuro-Oncology 2021cited by 76position: middledoi
The <i>EGFRvIII</i> transcriptome in glioblastoma: A meta-omics analysis
Neuro-Oncology 2021cited by 32position: middledoi
Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma
JAMA Oncology 2020cited by 1,426position: middledoi
A drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent local relapse and treat established brain metastasis
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 3position: middledoi
INTELLANCE 2/EORTC 1410 randomized phase II study of Depatux-M alone and with temozolomide vs temozolomide or lomustine in recurrent EGFR amplified glioblastoma
Neuro-Oncology 2019cited by 186position: middledoi
A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma
Journal of Neuro-Oncology 2019cited by 49position: middledoi
Trabectedin for recurrent WHO grade II or III meningioma: A randomized phase II study of the EORTC Brain Tumor Group (EORTC-1320-BTG).
Journal of Clinical Oncology 2019cited by 19position: middledoi
PL3.2 Trabectedin for recurrent WHO grade II or III meningioma: a randomized phase II study of the EORTC Brain Tumor Group (EORTC-1320-BTG)
Neuro-Oncology 2019cited by 8position: middledoi
ATIM-47. NIVOLUMAB VS BEVACIZUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA: EXPLORATORY ANALYSIS OF MGMT METHYLATION STATUS AND BASELINE CORTICOSTEROID USE
Neuro-Oncology 2019cited by 3position: middledoi
OS10.3 Randomized Phase 3 Study Evaluating the Efficacy and Safety of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma: CheckMate 143
Neuro-Oncology 2017cited by 323position: middledoi
Biomarker and Histopathology Evaluation of Patients with Recurrent Glioblastoma Treated with Galunisertib, Lomustine, or the Combination of Galunisertib and Lomustine
International Journal of Molecular Sciences 2017cited by 31position: middledoi
ACTR-74. A PHASE IB/II, OPEN-LABEL, MULTICENTER STUDY OF CAPMATINIB (INC280) ALONE AND IN COMBINATION WITH BUPARLISIB (BKM120) IN ADULT PATIENTS WITH RECURRENT GLIOBLASTOMA
Neuro-Oncology 2017cited by 1position: middledoi
A Phase II randomized study of galunisertib monotherapy or galunisertib plus lomustine compared with lomustine monotherapy in patients with recurrent glioblastoma
Neuro-Oncology 2016cited by 270position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Wolfgang Wick · Heidelberger Institut für Radioonkologie10 papers (2016–2024)Martin J. van den Bent · St James's University Hospital7 papers (2017–2025)Michael Weller · Center for Neurosciences7 papers (2019–2024)Patrick Y. Wen · Harvard University6 papers (2017–2025)Alba A. Brandes · AstraZeneca (Italy)5 papers (2016–2020)Riccardo Soffietti · European Institute of Oncology5 papers (2019–2024)Filip De Vos · Leidsche Rijn Julius Health Centers5 papers (2017–2022)Vassilis Golfinopoulos · European Organisation for Research and Treatment of Cancer4 papers (2019–2024)Antonio Silvani · Neurological Surgery4 papers (2019–2024)Petter Brandal · University of Oslo4 papers (2019–2024)Jordi Rodón · University of California San Francisco Medical Center4 papers (2016–2019)Thierry Gorlia · Aix-Marseille Université4 papers (2019–2024)Matthias Preusser · Comprehensive Cancer Center Vienna4 papers (2019–2024)Timothy F. Cloughesy · UCLA Medical Center4 papers (2022–2025)Émilie Le Rhun · University Hospital of Zurich4 papers (2019–2024)Andreas F. Hottinger · Ludwig Cancer Research3 papers (2023–2025)Warren Mason · University Health Network3 papers (2023–2025)Paul de Souza · Jaguar Land Rover (United Kingdom)3 papers (2017–2020)Michael Lim · Stanford University3 papers (2017–2020)Ingo K. Mellinghoff · University of Colorado Denver3 papers (2023–2025)
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