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Xian Adiconis

Massachusetts Institute of Technology · US
Area of research
Molecular Biology · Cancer Research
Research interest
Research focused on RNA and Transcriptome, with related work in Neuroscience, Computational biology, Single-cell analysis. Notable publications include 'Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells', 'Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics', and 'Individual brain organoids reproducibly form cell diversity of the human cerebral cortex'.
h-index
citations
9,812
works
28
NIH funding
primary concept
email

Recent publications

Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types
Nature Aging 2023cited by 68position: middledoi
Cell-type specific defects in<i>PTEN</i>-mutant cortical organoids converge on abnormal circuit activity
Human Molecular Genetics 2023cited by 23position: middledoi
Autism genes converge on asynchronous development of shared neuron classes
Nature 2022cited by 454position: middledoi
The evolution, evolvability and engineering of gene regulatory DNA
Nature 2022cited by 295position: middledoi
Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex
Cell 2022cited by 229position: middledoi
Mostly natural sequencing-by-synthesis for scRNA-seq using Ultima sequencing
Nature Biotechnology 2022cited by 52position: middledoi
Single cell RNA-seq by mostly-natural sequencing by synthesis
bioRxiv (Cold Spring Harbor Laboratory) 2022cited by 1position: middledoi
Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity
Genome biology 2021cited by 17position: middledoi
Systematic comparison of single-cell and single-nucleus RNA-sequencing methods
Nature Biotechnology 2020cited by 953position: middledoi
Benchmarking single-cell RNA-sequencing protocols for cell atlas projects
Nature Biotechnology 2020cited by 527position: middledoi
Distinct subnetworks of the thalamic reticular nucleus
Nature 2020cited by 208position: middledoi
Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genes
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 20position: middledoi
Author Correction: Systematic comparison of single-cell and single-nucleus RNA-sequencing methods
Nature Biotechnology 2020cited by 16position: middledoi
Individual brain organoids reproducibly form cell diversity of the human cerebral cortex
Nature 2019cited by 1,109position: middledoi
Single-cell transcriptomic profiling of the aging mouse brain
Nature Neuroscience 2019cited by 777position: middledoi
Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes
Neuron 2019cited by 642position: middledoi
Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas Projects
bioRxiv (Cold Spring Harbor Laboratory) 2019cited by 29position: middledoi
TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
Cell 2018cited by 455position: middledoi
Comprehensive comparative analysis of 5′-end RNA-sequencing methods
Nature Methods 2018cited by 140position: firstdoi
Effects of 3D culturing conditions on the transcriptomic profile of stem-cell-derived neurons
Nature Biomedical Engineering 2018cited by 103position: middledoi
Author Correction: Comprehensive comparative analysis of 5′-end RNA-sequencing methods
Nature Methods 2018cited by 5position: firstdoi
RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease
Proceedings of the National Academy of Sciences 2017cited by 373position: middledoi
Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics
Cell 2016cited by 1,300position: middledoi
Massively Parallel Sequencing of Human Urinary Exosome/Microvesicle RNA Reveals a Predominance of Non-Coding RNA
PLoS ONE 2014cited by 126position: middledoi
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
Nature 2013cited by 1,301position: middledoi
Comprehensive comparative analysis of RNA sequencing methods for degraded or low input samples
Digital Access to Scholarship at Harvard (DASH) (Harvard University) 2013cited by 549position: firstdoi
Comparative analysis of RNA sequencing methods for degraded or low-input samples
Nature Methods 2013cited by 35position: firstdoi
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
2013cited by 5position: middle

Grants

No grants ingested yet.

Frequent collaborators

Joshua Z. Levin · Massachusetts Institute of Technology24 papers (2013–2023)Aviv Regev · Moscow Institute of Thermal Technology18 papers (2013–2023)Sean Simmons · Massachusetts Institute of Technology12 papers (2018–2023)Amanda J. Kedaigle · Massachusetts Institute of Technology6 papers (2019–2023)Lan Nguyễn · Broad Institute5 papers (2019–2023)Alex K. Shalek · Broad Institute4 papers (2013–2020)Bruna Paulsen · Harvard Stem Cell Institute4 papers (2019–2023)Xi Shi · Massachusetts Institute of Technology4 papers (2018–2021) · 4 papers (2013–2018)Jen Q. Pan · Massachusetts Institute of Technology4 papers (2018–2021)Paola Arlotta · Harvard Stem Cell Institute4 papers (2019–2023)Nir Hacohen · Broad Institute4 papers (2013–2020)Silvia Velasco · New York University4 papers (2019–2023)Orit Rozenblatt–Rosen · Broad Institute4 papers (2020–2022) · 4 papers (2018–2021) · 3 papers (2020–2023) · 3 papers (2013–2013) · 3 papers (2016–2020)Danielle Dionne · Broad Institute3 papers (2018–2023)Andrey Sivachenko · Cystic Fibrosis Foundation3 papers (2013–2014)