Area of research
Immunology · Oncology
Research interest
Deficiencies in nucleases that degrade DNA lead to accumulation of self DNA, activation of innate immune responses and development of autoimmune disorders, including systemic lupus erythematosus and Aicardi-Goutières syndrome in humans, and autoimmune arthritis, nephritis and myocarditis in mice. We have been interested in understanding how autoimmunity develops upon triggering of innate immunity by self DNA (rather than pathogen-derived DNA). In studying this question, we made the surprising observation that immunostimulatory DNA can arise from host damaged DNA that is exported from the nucleus to the lysosome (Lan et al., Cell Rep 2014). We hypothesize that this cellular process is a source of inflammation in autoimmunity, cancer, chemotherapy and aging (Lan et al., Aging Cell 2019).
A neoantigen vaccine generates antitumour immunity in renal cell carcinoma
Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis
Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis
A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis
Single-cell image-based screens identify host regulators of Ebola virus infection dynamics
Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants
Unveiling alternative splicing dynamics in activated T lymphocytes and their implications for immune checkpoint blockade efficacy
Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics
Specific oncogene activation of the cell of origin in mucosal melanoma
Spatially defined multicellular functional units in colorectal cancer revealed from single cell and spatial transcriptomics
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy
Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis
Urine proteomic signatures of histological class, activity, chronicity, and treatment response in lupus nephritis
The chromatin landscape of healthy and injured cell types in the human kidney
Proximity-dependent labeling identifies dendritic cells that drive the tumor-specific CD4 <sup>+</sup> T cell response
The commitment of the human cell atlas to humanity
Cryoablation and post-progression immune checkpoint inhibition in metastatic melanoma: a phase II trial
Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue
An atlas of healthy and injured cell states and niches in the human kidney
<i>CXCL9:SPP1</i> macrophage polarity identifies a network of cellular programs that control human cancers
Dictionary of immune responses to cytokines at single-cell resolution
Human STING is a proton channel
Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer
Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial
High-throughput RNA isoform sequencing using programmed cDNA concatenation
Targeting TBK1 to overcome resistance to cancer immunotherapy
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling
Low protease activity in B cell follicles promotes retention of intact antigens after immunization
Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients