Area of research
Molecular Biology · Structural Biology
Research interest
Research interests include Ubiquitin and proteasome pathways, Advanced Electron Microscopy Techniques and Applications, Autophagy in Disease and Therapy, and Endoplasmic Reticulum Stress and Disease.
Metabolic environment-driven remodeling of mitochondrial ribosomes regulates translation and biogenesis
Dynamic allostery drives autocrine and paracrine TGF-β signaling
Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking
Dodecamer assembly of a metazoan AAA <sup>+</sup> chaperone couples substrate extraction to refolding
Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
General and robust covalently linked graphene oxide affinity grids for high-resolution cryo-EM
Ion transport and regulation in a synaptic vesicle glutamate transporter
Protein nanoribbons template enamel mineralization
Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating
Molecular goniometers for single-particle cryo-electron microscopy of DNA-binding proteins
Enhancing the signal-to-noise ratio and generating contrast for cryo-EM images with convolutional neural networks
Allosteric coupling between α-rings of the 20S proteasome
Stoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry
Amino and PEG-amino graphene oxide grids enrich and protect samples for high-resolution single particle cryo-electron microscopy
A simple and robust procedure for preparing graphene-oxide cryo-EM grids
Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body