Area of research
Immunology · Genetics
Research interest
Research interests include T-cell and B-cell Immunology, Immune Cell Function and Interaction, Immunotherapy and Immune Responses, and Diabetes and associated disorders.
Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development
Islet-reactive CD8 <sup>+</sup> T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors
T cells specific for post-translational modifications escape intrathymic tolerance induction
An efficient protocol for in vivo labeling of proliferating epithelial cells
Revisiting the Road Map of Medullary Thymic Epithelial Cell Differentiation
Epitope-Specific Tolerance Modes Differentially Specify Susceptibility to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis
Dissecting and modeling the emergent murine TEC compartment during ontogeny
Re-examining the Nature and Function of Self-Reactive T cells
Myelin oligodendrocyte glycoprotein induces incomplete tolerance of CD4<sup>+</sup>T cells specific for both a myelin and a neuronal self‐antigen in mice
A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β
The role of bone marrow promiscuous gene expression in peripheral tolerance
Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction
Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells
Homeodomain-Interacting Protein Kinase 2, a Novel Autoimmune Regulator Interaction Partner, Modulates Promiscuous Gene Expression in Medullary Thymic Epithelial Cells
Evolutionary conserved gene co-expression drives generation of self-antigen diversity in medullary thymic epithelial cells
Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome
Thymic Epithelial Cells Are a Nonredundant Source of Wnt Ligands for Thymus Development
3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression
Genome-wide gene expression profiling of homeodomain-interacting protein kinase 2 deficient medullary thymic epithelial cells
3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression
Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
Adult Thymus Contains FoxN1− Epithelial Stem Cells that Are Bipotent for Medullary and Cortical Thymic Epithelial Lineages
Misinitiation of intrathymic <i>MART‐1</i> transcription and biased TCR usage explain the high frequency of MART‐1‐specific T cells
Love Is in the Aire: mTECs Share Their Assets
Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity
An evolutionarily conserved mutual interdependence between <scp>A</scp>ire and micro<scp>RNA</scp>s in promiscuous gene expression
An Organotypic Coculture Model Supporting Proliferation and Differentiation of Medullary Thymic Epithelial Cells and Promiscuous Gene Expression