Area of research
Molecular Biology · Cancer Research
Research interest
Research focused on Amplicon and Cancer, with related work in Non-homologous end joining, Molecular biology, Cancer research. Notable publications include 'Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells', 'Circulating mitochondria DNA, a non-invasive cancer diagnostic biomarker candidate', and 'Expulsion of micronuclei containing amplified genes contributes to a decrease in double minute chromosomes from malignant tumor cells'.
Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance
TOB1 inhibits the gastric cancer progression by focal adhesion pathway and ERK pathway based on transcriptional and metabolic sequencing
Expression, DNA methylation pattern and transcription factor EPB41L3 in gastric cancer: a study of 262 cases
TOB1 modulates neutrophil phenotypes to influence gastric cancer progression and immunotherapy efficacy
MIEN1 on the 17q12 amplicon facilitates the malignant behaviors of gastric cancer via activating IL-6/JAK2/STAT3 pathway
Contribution of <scp>PGAP3</scp> co‐amplified and co‐overexpressed with <scp>ERBB2</scp> at 17q12 involved poor prognosis in gastric cancer
The Overexpression of TOB1 Induces Autophagy in Gastric Cancer Cells by Secreting Exosomes
Involvement of TOB1 on autophagy in gastric cancer AGS cells <i>via</i> decreasing the activation of AKT/mTOR signaling pathway
The promoter methylation drives down-regulation mode of HIC1 in gastric cancer, its molecular characteristics and downstream functional pathways
Genetic Diversity Analysis of the Chinese Daur Ethnic Group in Heilongjiang Province by Complete Mitochondrial Genome Sequencing
Analysis of DNA Repair-Related Prognostic Function and Mechanism in Gastric Cancer
Multidimensional difference analysis in gastric cancer patients between high and low latitude
Differential Infiltration of Immune Cells Driven by Tumor Heterogeneity Reveals Two Immune Subtypes in Lung Adenocarcinoma
The functional variant in promoter of OVCA1 was associated with the risk of gastric cancer in the northeast Chinese Han population
Genetic Polymorphism of Drug Metabolic Gene CYPs, VKORC1, NAT2, DPYD and CHST3 of Five Ethnic Minorities in Heilongjiang Province, Northeast China
The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the Han population in Northeast China
Molecular structure and evolution mechanism of two populations of double minutes in human colorectal cancer cells
Association between HIC1 promoter methylation and solid tumor: A meta-analysis
Prevalence of chromosomal abnormalities identified by copy number variation sequencing in high-risk pregnancies, spontaneous abortions, and suspected genetic disorders
Decreased expression levels of DAL-1 and TOB1 are associated with clinicopathological features and poor prognosis in gastric cancer
Phosphorylation of TOB1 at T172 and S320 is critical for gastric cancer proliferation and progression.
PubMed 2019cited by 8position: last
Identification of a pathogenic mutation in a Chinese pedigree with polycystic kidney disease
Circulating mitochondria DNA, a non-invasive cancer diagnostic biomarker candidate
Association between the SNPs of the <i>TOB1</i> gene and gastric cancer risk in the Chinese Han population of northeast China
Associations between PTPN2 gene polymorphisms and psoriasis in Northeastern China
Decreased TOB1 expression and increased phosphorylation of nuclear TOB1 promotes gastric cancer
Association between the<i>BRCA2</i>rs144848 polymorphism and cancer susceptibility: a meta-analysis
Aberrant expression of the candidate tumor suppressor gene DAL-1 due to hypermethylation in gastric cancer
Met promotes the formation of double minute chromosomes induced by Sei-1 in NIH-3T3 murine fibroblasts
The polymorphisms of MSH6 gene are associated with AIDS progression in a northern Chinese population