Area of research
Molecular Biology · Cancer Research
Research interest
Research focused on Cancer research and Molecular biology, with related work in Gene knockdown, Non-homologous end joining, Extrachromosomal DNA. Notable publications include 'Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells', 'Inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in methotrexate‐resistant colon cancer cells', and 'Gemcitabine Eliminates Double Minute Chromosomes from Human Ovarian Cancer Cells'.
Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance
TOB1 inhibits the gastric cancer progression by focal adhesion pathway and ERK pathway based on transcriptional and metabolic sequencing
Modulation of miR-466d-3p on Wnt signaling pathway in response to DEPs-induced blood-brain barrier disruption
Novel insights into the ecDNA formation mechanism involving MSH3 in methotrexate‑resistant human colorectal cancer cells
The relationship between epigenetic modifications and genomic instability of tumor cells
Non-homologous end joining repair of DNA double-strand breaks and its clinical application
Inhibiting homologous recombination decreases extrachromosomal amplification but has no effect on intrachromosomal amplification in methotrexate‐resistant colon cancer cells
Combined caveolin‑1 and epidermal growth factor receptor expression as a prognostic marker for breast cancer
A new type of non-coding RNA: circular RNA
TRIB1 promotes colorectal cancer cell migration and invasion through activation MMP-2 via FAK/Src and ERK pathways
Decreased TOB1 expression and increased phosphorylation of nuclear TOB1 promotes gastric cancer
SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer
Met promotes the formation of double minute chromosomes induced by Sei-1 in NIH-3T3 murine fibroblasts
Intratumor heterogeneity and its implications for tumor treatment
RETRACTED: Ribosomal L22-like1 (RPL22L1) Promotes Ovarian Cancer Metastasis by Inducing Epithelial-to-Mesenchymal Transition
Expression of pY397 FAK promotes the development of non-small cell lung cancer
Association between sister chromatid exchange and double minute chromosomes in human tumor cells
Predicting Chemosensitivity to Gemcitabine and Cisplatin Based on Gene Polymorphisms and mRNA Expression in Non-Small-Cell Lung Cancer Cells
Homologous recombination and genomic instability
The relationship between A- NHEJ and DNA double-strand breaks repair
Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells
S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-β signaling pathway in cancer cells
Constitutive <scp>ERK1</scp>/2 activation contributes to production of double minute chromosomes in tumour cells
Gemcitabine Eliminates Double Minute Chromosomes from Human Ovarian Cancer Cells
Expulsion of micronuclei containing amplified genes contributes to a decrease in double minute chromosomes from malignant tumor cells
<i>De novo</i>‐generated small palindromes are characteristic of amplicon boundary junction of double minutes
Elevated expression of astrocyte elevated gene‐1 (AEG‐1) is correlated with cisplatin‐based chemoresistance and shortened outcome in patients with stages III–IV serous ovarian carcinoma
Differential Expression of PAI-RBP1, C1orf142, and COTL1 in Non–Small Cell Lung Cancer Cell Lines with Different Tumor Metastatic Potential
Association of Single Nucleotide Polymorphisms in TCF2 with Type 2 Diabetes Susceptibility in a Han Chinese Population
Progress in the research of pharmacogenomics by cell line models