Area of research
Molecular Biology · Ecology
Research interest
Research focused on CRISPR and RNA, with related work in Antitoxin, Computational biology, Endoribonuclease. Notable publications include 'High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding', 'CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference', and 'Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System'.
Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle
A phage-encoded RNA-binding protein inhibits the antiviral activity of a toxin–antitoxin system
The evolution of a counter-defense mechanism in a virus constrains its host range
Shutoff of host transcription triggers a toxin-antitoxin system to cleave phage RNA and abort infection
A Simple, Cost-Effective, and Robust Method for rRNA Depletion in RNA-Sequencing Studies
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System
CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference