Area of research
Molecular Biology · Organic Chemistry
Research interest
Research interests include DNA Repair Mechanisms, Click Chemistry and Applications, Histone Deacetylase Inhibitors Research, and Cancer therapeutics and mechanisms.
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors
DNA polymerase theta protects leukemia cells from metabolic-induced DNA damage
Polθ reverse transcribes RNA and promotes RNA-templated DNA repair
The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining
Preferential D-loop extension by a translesion DNA polymerase underlies error-prone recombination
DNA polymerases are error-prone at RecA-mediated recombination intermediates