Area of research
Physiology · Molecular Biology
Research interest
Research interests include Biology, Telomere, Mitochondrial DNA, Cell biology, Polymerase, and DNA polymerase.
Engineering mtDNA deletions by reconstituting end joining in human mitochondria
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis
Identification of <b>RP-6685</b>, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ
Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance
Alternative splicing is a developmental switch for hTERT expression
DNA polymerase theta (Polθ) – an error-prone polymerase necessary for genome stability
Single-Molecule Imaging of Telomerase RNA Reveals a Recruitment-Retention Model for Telomere Elongation
Safeguarding mitochondrial genomes in higher eukaryotes
The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion
Stop pulling my strings — what telomeres taught us about the DNA damage response
Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis
Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination
ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres
Nontelomeric Role for Rap1 in Regulating Metabolism and Protecting against Obesity