Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include Mitochondrial Function and Pathology, Cancer, Hypoxia, and Metabolism, ATP Synthase and ATPases Research, and Heat shock proteins research.
Second international symposium on the chaperone code, 2023
The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation
MAPK15 protects from oxidative stress‐dependent cellular senescence by inducing the mitophagic process
Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3
Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters
Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase
The molecular chaperone TRAP1 in cancer: From the basics of biology to pharmacological targeting
SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern
HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia
Targeting the mitochondrial chaperone TRAP1: strategies and therapeutic perspectives
Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca2+‐dependent death of cancer cells
Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1
Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming
The Answer Lies in the Energy: How Simple Atomistic Molecular Dynamics Simulations May Hold the Key to Epitope Prediction on the Fully Glycosylated SARS-CoV-2 Spike Protein
Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression
Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1
S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli
Machine Learning of Allosteric Effects: The Analysis of Ligand-Induced Dynamics to Predict Functional Effects in TRAP1
Progressively De-Differentiated Pancreatic Cancer Cells Shift from Glycolysis to Oxidative Metabolism and Gain a Quiescent Stem State
The zebrafish orthologue of the human hepatocerebral disease gene<i>MPV17</i>plays pleiotropic roles in mitochondria
Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer
Metabolic Plasticity of Tumor Cell Mitochondria
The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells
Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1
Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads
Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis
<i>S</i> -nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology
Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death
GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop