Area of research
Molecular Biology · Cancer Research
Research interest
Research focused on Mitochondrion and ATP synthase, with related work in Neurofibromin 1, Cell biology, Hexokinase. Notable publications include 'Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters', 'Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca2+‐dependent death of cancer cells', and 'Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1'.
The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation
Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3
Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters
Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase
Hexokinase 2 displacement from mitochondria‐associated membranes prompts Ca2+‐dependent death of cancer cells
Metabolic Plasticity of Tumor Cell Mitochondria
Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1
Gold(III)–pyrrolidinedithiocarbamato Derivatives as Antineoplastic Agents
Hepatic progenitor cells express SerpinB3
SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I