Area of research
Immunology · Molecular Biology
Research interest
Research focused on Cell biology and Notch signaling pathway, with related work in Wnt signaling pathway, Metastasis, Cancer research. Notable publications include 'Notch signalling drives synovial fibroblast identity and arthritis pathology', 'Endothelial Notch1 Activity Facilitates Metastasis', and 'Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis'.
Epiregulon: Single-cell transcription factor activity inference to predict drug response and drivers of cell states
Notch signaling in thyrocytes is essential for adult thyroid function and mammalian homeostasis
Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway
Notch signalling drives synovial fibroblast identity and arthritis pathology
Heterotypic cell–cell communication regulates glandular stem cell multipotency
AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer
Heterogeneity of Satellite Cells Implicates DELTA1/NOTCH2 Signaling in Self-Renewal
Rapid Crypt Cell Remodeling Regenerates the Intestinal Stem Cell Niche after Notch Inhibition
Notch Regulates Innate Lymphoid Cell Plasticity during Human NK Cell Development
A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage
Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell–Dependent Mechanisms
Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells
Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice
Endothelial Notch1 Activity Facilitates Metastasis
Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair
Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis
The Hedgehog Hold on Homeostasis
Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates
Differential effects of targeting Notch receptors in a mouse model of liver cancer