Area of research
Molecular Biology
Research interest
Research interests include Bioinformatics and Genomic Networks, Genomics and Chromatin Dynamics, Gene Regulatory Network Analysis, and Gene expression and cancer classification.
Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice.
Current and future directions in network biology
Inference of cell type-specific gene regulatory networks on cell lineages from single cell omic datasets.
Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variation.
A network-based model of <i>Aspergillus fumigatus</i> elucidates regulators of development and defensive natural products of an opportunistic pathogen
Benchmarking graph representation learning algorithms for detecting modules in molecular networks
Single-nuclei transcriptome analysis of the shoot apex vascular system differentiation in Populus.
Modular derivation of diverse, regionally discrete human posterior CNS neurons enables discovery of transcriptomic patterns.
Temporal change in chromatin accessibility predicts regulators of nodulation in Medicago truncatula.
Functional and comparative genomics reveals conserved noncoding sequences in the nitrogen-fixing clade.
Inference of cell type-specific gene regulatory networks on cell lineages from single cell omic datasets
The NIH Somatic Cell Genome Editing program
GRiNCH: simultaneous smoothing and detection of topological units of genome organization from sparse chromatin contact count matrices with matrix factorization.
Modular Derivation and Unbiased Single-cell Analysis of Regional Human Hindbrain And Spinal Neurons Enables Discovery of Nuanced Transcriptomic Patterns along Developmental Axes
Imputed gene associations identify replicable <i>trans</i> ‐acting genes enriched in transcription pathways and complex traits
Inference and Evolutionary Analysis of Genome-Scale Regulatory Networks in Large Phylogenies
Comparative Analysis of Gene Regulatory Networks: From Network Reconstruction to Evolution
Evolutionary principles of modular gene regulation in yeasts
Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome