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Manolis Kellis

Broad Institute · US
Area of research
Molecular Biology
Research interest
Research interests include Genomics and Chromatin Dynamics, RNA and protein synthesis mechanisms, Genomics and Phylogenetic Studies, and Single-cell and spatial transcriptomics.
h-index
140
citations
125,186
works
1,142
NIH funding
primary concept
Biology
email

Recent publications

Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue
bioRxiv (Cold Spring Harbor Laboratory) 2026cited by 0position: middledoi
Complete sequencing of ape genomes
Nature 2025cited by 118position: middledoi
Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience
Cell 2025cited by 31position: lastdoi
Multi-omics analysis of a pig-to-human decedent kidney xenotransplant
Nature 2025cited by 12position: middledoi
Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanoma
Nature Communications 2025cited by 12position: lastdoi
Translon: a single term for translated regions
Nature Methods 2025cited by 10position: middledoi
Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants
Cell Reports Medicine 2025cited by 9position: middledoi
Engineered 3D immuno-glial-neurovascular human miBrain model
Proceedings of the National Academy of Sciences 2025cited by 7position: middledoi
ABCA7 variants impact phosphatidylcholine and mitochondria in neurons
Nature 2025cited by 5position: middledoi
Multisensory gamma stimulation enhances adult neurogenesis and improves cognitive function in male mice with Down Syndrome
PLoS ONE 2025cited by 4position: middledoi
Specific oncogene activation of the cell of origin in mucosal melanoma
Nature Communications 2025cited by 1position: middledoi
Proteogenomics-enabled discovery of novel small open reading frame (sORF)-encoded polypeptides in human and mouse tissues
Nucleic Acids Research 2025cited by 0position: middledoi
Multisensory gamma stimulation promotes glymphatic clearance of amyloid
Nature 2024cited by 285position: middledoi
Single-cell multiregion dissection of Alzheimer’s disease
Nature 2024cited by 253position: lastdoi
Single-cell multi-cohort dissection of the schizophrenia transcriptome
Science 2024cited by 125position: middledoi
Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD
Cell 2024cited by 89position: lastdoi
Massively parallel characterization of regulatory elements in the developing human cortex
Science 2024cited by 61position: middledoi
Integrative multi-omics profiling in human decedents receiving pig heart xenografts
Nature Medicine 2024cited by 55position: middledoi
Leveraging single-cell ATAC-seq and RNA-seq to identify disease-critical fetal and adult brain cell types
Nature Communications 2024cited by 42position: middledoi
Gamma entrainment using audiovisual stimuli alleviates chemobrain pathology and cognitive impairment induced by chemotherapy in mice
Science Translational Medicine 2024cited by 33position: middledoi
Antigen presenting cells in cancer immunity and mediation of immune checkpoint blockade
Clinical & Experimental Metastasis 2024cited by 30position: middledoi
Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery
Nature Neuroscience 2024cited by 28position: middledoi
Complete sequencing of ape genomes
bioRxiv (Cold Spring Harbor Laboratory) 2024cited by 25position: middledoi
TDP-43 proteinopathy in ALS is triggered by loss of ASRGL1 and associated with HML-2 expression
Nature Communications 2024cited by 25position: middledoi
The single-cell opioid responses in the context of HIV (SCORCH) consortium
Molecular Psychiatry 2024cited by 16position: middledoi
Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases
Cell Genomics 2024cited by 14position: middledoi
Targeting IL-1 controls refractory pityriasis rubra pilaris
Science Advances 2024cited by 12position: middledoi
Author Correction: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
Nature 2024cited by 7position: middledoi
ProCyon: A multimodal foundation model for protein phenotypes
bioRxiv (Cold Spring Harbor Laboratory) 2024cited by 7position: middledoi
Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing
eLife 2024cited by 5position: middledoi

Grants

CAREER: Comparative Genomics and Biological Signal Discovery in the Human Genome
NSF0644282$1,067,3092007–2014PIRePORTER

Frequent collaborators

Li‐Huei Tsai · Broad Institute23 papers (2015–2025)José Dávila-Velderrain · Human Technopole15 papers (2017–2024)Na Sun · University of Baltimore14 papers (2022–2024)Carles A. Boix · Broad Institute11 papers (2020–2026)Hansruedi Mathys · University of Pittsburgh11 papers (2019–2025)Irwin Jungreis · Massachusetts Institute of Technology11 papers (2014–2025)Myriam Heiman · McGovern Institute for Brain Research9 papers (2020–2024)David A. Bennett · Texas Children's Hospital9 papers (2019–2023)Xueqiao Jiang · McGovern Institute for Brain Research9 papers (2019–2025)Lei Jin · Hohai University8 papers (2023–2024)Liang He · Massachusetts Institute of Technology8 papers (2018–2025)Bosiljka Tasic · Allen Institute for Brain Science8 papers (2023–2024)S. Sebastian Pineda · Massachusetts Institute of Technology8 papers (2020–2025)Heather A. Sullivan · McGovern Institute for Brain Research8 papers (2023–2024)Hyeseung Lee · Massachusetts Institute of Technology8 papers (2020–2024)Yongjin Park · Yale University8 papers (2020–2023)Aixin Zhang · Allen Institute for Brain Science8 papers (2023–2024)Shenqin Yao · Allen Institute for Brain Science8 papers (2023–2024)Makoto Matsuyama · Juntendo University8 papers (2023–2024)Kyriaki Galani · Broad Institute7 papers (2021–2024)