Area of research
Molecular Biology · Biotechnology
Research interest
Research focused on Cancer research and Metastasis, with related work in Colorectal cancer, Wnt signaling pathway, Breast cancer. Notable publications include 'TRIP13 promotes metastasis of colorectal cancer regardless of p53 and microsatellite instability status', 'DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer', and 'PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer'.
Combination of dual JAK/HDAC inhibitor with regorafenib synergistically reduces tumor growth, metastasis, and regorafenib-induced toxicity in colorectal cancer
Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma
BZW2 Inhibition Reduces Colorectal Cancer Growth and Metastasis
Microbiome diversity in African American, European American, and Egyptian colorectal cancer patients
Molecular disparities in colorectal cancers of White Americans, Alabama African Americans, and Oklahoma American Indians
DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer
A signature of Prevotella copri and Faecalibacterium prausnitzii depletion, and a link with bacterial glutamate degradation in the Kenyan colorectal cancer patients
Comparative analysis of triple-negative breast cancer transcriptomics of Kenyan, African American and Caucasian Women
Immunophenotype‐associated gene signature in ductal breast tumors varies by receptor subtype, but the expression of individual signature genes remains consistent
TRIP13 promotes metastasis of colorectal cancer regardless of p53 and microsatellite instability status
PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer
Targeting P4HA1 with a Small Molecule Inhibitor in a Colorectal Cancer PDX Model
Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated with African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations
PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression