Area of research
Pharmacology · Hepatology
Research interest
Research interests include Liver physiology and pathology, Pharmacogenetics and Drug Metabolism, Drug-Induced Hepatotoxicity and Protection, and Pluripotent Stem Cells Research.
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study
Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds
Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication
Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes