Area of research
Pharmacology · Oncology
Research interest
Research interests include Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Liver physiology and pathology, and Drug-Induced Hepatotoxicity and Protection.
Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis
Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study
Three-Dimensional Spheroid Primary Human Hepatocytes in Monoculture and Coculture with Nonparenchymal Cells
Cytochrome P450 Induction and Xeno‐Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator‐Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication
Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing
Hepatocyte-based in vitro model for assessment of drug-induced cholestasis
Transcriptomic Hepatotoxicity Signature of Chlorpromazine after Short- and Long-Term Exposure in Primary Human Sandwich Cultures